What is the recommended dosage for Omega-3 Fatty Acids (EPA/DHA)?

General: 250-500 mg combined EPA/DHA/day; Anti Inflammatory: 1,000-3,000 mg combined EPA/DHA/day

What are the side effects of Omega-3 Fatty Acids (EPA/DHA)?

Potential side effects include: Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses.

What is omega-3 and how does it support immune function?

Omega-3 fatty acids (EPA and DHA) are essential polyunsaturated fats found in fish oil and algae. They play a role in resolving inflammation through specialized pro-resolving mediators (SPMs) and have been studied for their effects on immune cell membrane function.

What dosage of omega-3 has been studied for immune-related outcomes?

Clinical trials have used omega-3 doses of 1–4 g per day of combined EPA and DHA. For immune and anti-inflammatory outcomes, doses of 2–3 g per day are common, typically studied over periods of 8 to 16 weeks.

What are the potential side effects of omega-3 supplementation?

Common side effects include fishy aftertaste, burping, and mild gastrointestinal effects. High doses (above 3 g per day) may increase bleeding risk and should be discussed with a healthcare provider, especially before surgery or if taking anticoagulants.

Omega-3 Fatty Acids (EPA/DHA)
Omega-3 Fatty Acids (EPA/DHA)

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يُعرف أيضاً بـ: Fish Oil, Eicosapentaenoic Acid, Docosahexaenoic Acid, Marine Omega-3

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EPA and DHA alter cell membrane phospholipid composition and give rise to specialized pro-resolving mediators (resolvins, protectins, maresins) that actively resolve inflammation. The VITAL trial showed a 15% reduction in autoimmune disease risk. DHA showed stronger anti-inflammatory effects than EPA in randomized studies.

How It Works

EPA and DHA alter cell membrane phospholipid composition and give rise to specialized pro-resolving mediators (resolvins, protectins, maresins); EPA inhibits NF-kB activation; DHA suppresses pro-inflammatory gene expression.

Evidence For Conditions

الحالة	التقييم	الدراسات	المشاركون
Chronic Inflammation	A	30	30000	عرض →
Autoimmune Conditions	B	10	25000	عرض →

Side Effects

Fishy aftertaste and burping
Gastrointestinal discomfort (nausea, diarrhea)
Increased bleeding risk at high doses
Potential LDL cholesterol increase at very high doses

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Blood pressure medications (additive blood pressure lowering)
Orlistat (may reduce omega-3 absorption)
Cyclosporine (may modify immunosuppressive effects)

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Related Ingredients

Conjugated Linoleic Acid

حقائق سريعة

الجرعة: General: 250-500 mg combined EPA/DHA/day; Anti_Inflammatory: 1,000-3,000 mg combined EPA/DHA/day
الأشكال الدوائية: softgel liquid capsule
المصادر الطبيعية: Salmon, Mackerel, Sardines, Anchovies, Walnuts, Flaxseed
الحد الأعلى: 3,000 mg/day EPA+DHA (FDA-recognized as safe)
أفضل وقت: With meals

ملخص الأدلة

Chronic Inflammation A

Autoimmune Conditions B

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