Vitamin D के लिए Autoimmune Conditions

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

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निष्कर्ष

Key Study Findings

Review

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.

Dose: None बनाम: None Outcome: rheumatoid arthritis disease activity modulation through diet प्रभाव: None None

जनसंख्या: patients with rheumatoid arthritis

Review

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …

Dose: None बनाम: None Outcome: RA risk and disease activity प्रभाव: None None

जनसंख्या: Patients with rheumatoid arthritis

Review

Hypoparathyroidism: diagnosis, management and emerging therapies.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: None

Systematic Review

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.

Dose: None बनाम: None Outcome: None प्रभाव: None None

जनसंख्या: Systematic review of nutraceuticals in rheumatoid arthritis

Controlled Clinical Trial 26 weeks

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.

Dose: 4000 IU or 8000 IU daily बनाम: No supplementation Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI) प्रभाव: None None

जनसंख्या: SLE patients (EULAR/ACR 2019 criteria)

Review

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.

Dose: None बनाम: None Outcome: Neuroprotection प्रभाव: None None

जनसंख्या: None

Key Statistics

अध्ययन

25871

प्रतिभागी

↑

Positive

ग्रेड

Referenced Papers

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity. Review

Nutrients 2026

Hypoparathyroidism: diagnosis, management and emerging therapies. Review

Nature reviews. Endocrinology 2025 14 उद्धरण

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions. Systematic Review

Inflammopharmacology 2025 1 उद्धरण

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review. Review

Nutrients 2025

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus. Other

Cureus 2025

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled … RCT

Arthritis & rheumatology … 2024 25 उद्धरण

Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity. Review

Immunity & ageing … 2024 12 उद्धरण

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Review

Frontiers in immunology 2024 9 उद्धरण

Auto-immuno-deficiency syndromes. Review

Autoimmunity reviews 2024 6 उद्धरण

Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics. Review

Biochemical pharmacology 2024 6 उद्धरण

Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata. Other

Indian dermatology online … 2024 3 उद्धरण

The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study. Systematic Review

Nutrients 2024 2 उद्धरण

Vitamin D and Autoimmune Rheumatic Diseases. Review

Biomolecules 2023 70 उद्धरण

Nutrition and its role in prevention and management of rheumatoid arthritis. Review

Autoimmunity reviews 2023 65 उद्धरण

Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. Review

The American journal … 2023 37 उद्धरण

Differential impact of environmental factors on systemic and localized autoimmunity. Review

Frontiers in immunology 2023 33 उद्धरण

Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. Review

Nutrients 2023 24 उद्धरण

Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Other

Seminars in arthritis … 2023 17 उद्धरण

The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. Review

Mini reviews in … 2023 9 उद्धरण

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study. Other

Journal of cosmetic … 2023 4 उद्धरण

Determination of Serum 25-Hydroxyvitamin D Levels in Patients with Alopecia Areata. Other

Journal of Nepal … 2023

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. RCT

BMJ (Clinical research … 2022 307 उद्धरण

Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Review

International journal of … 2022 102 उद्धरण

Autoimmune disease and interconnections with vitamin D. Review

Endocrine connections 2022 50 उद्धरण

Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … RCT

Nutrients 2022 29 उद्धरण

Tuberculosis and Autoimmunity. Review

Pathophysiology : the … 2022 24 उद्धरण

Vitamin D in Prevention of Autoimmune Diseases. Review

Frontiers in bioscience … 2022 17 उद्धरण

Evaluation of several immune and inflammatory indicators and their association with alopecia areata. Other

Journal of cosmetic … 2022 11 उद्धरण

Vitamin D and fish oil supplements and risk of autoimmune disease. Other

BMJ (Clinical research … 2022 9 उद्धरण

[Vitamin D like one of few prevention possibilities for autoimmune diseases?]. RCT

Nederlands tijdschrift voor … 2022 1 उद्धरण

Epidemiology of Non-Hodgkin's Lymphoma. Review

Medical sciences (Basel, … 2021 157 उद्धरण

Alopecia Universalis Occurring after Alemtuzumab Treatment for Multiple Sclerosis. A Two-Year Follow-Up of Two Patients. Case Report

International journal of … 2021 6 उद्धरण

Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A … Other

JAAD international 2021 5 उद्धरण

Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations? Review

Nutrients 2020 229 उद्धरण

Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Review

Calcified tissue international 2020 185 उद्धरण

Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle? Review

Nutrients 2020 41 उद्धरण

Vitamin D in autoimmune bullous disease. Review

Acta biochimica Polonica 2020 10 उद्धरण

Epigenetics in Multiple Sclerosis. Review

Advances in experimental … 2020 8 उद्धरण

Systemic lupus erythematosus: Diagnosis and clinical management. Review

Journal of autoimmunity 2019 604 उद्धरण

Vitamin D and Human Health. Other

International journal of … 2019 109 उद्धरण

The genetics of vitamin D. Review

Bone 2019 62 उद्धरण

Vitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis. Other

Therapeutics and clinical … 2019 4 उद्धरण

Vitamin D, the gut microbiome and inflammatory bowel disease. Review

Journal of research … 2018 48 उद्धरण

[Early reumatoid arthritis]. Review

Wiadomosci lekarskie (Warsaw, … 2018 2 उद्धरण

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. Review

Thyroid : official … 2017 170 उद्धरण

Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Review

The Israel Medical … 2017 117 उद्धरण

Cholesterolomics: An update. Review

Analytical biochemistry 2017 47 उद्धरण

Vitamin D Deficiency and Rheumatoid Arthritis. Review

Clinical reviews in … 2017 46 उद्धरण

25-hydroxyvitamin D status in patients with alopecia areata. Other

Postepy dermatologii i … 2017 31 उद्धरण

Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. Review

Current medicinal chemistry 2017 14 उद्धरण

Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis. Meta-Analysis

PloS one 2016 152 उद्धरण

Vitamin D and autoimmunity. Review

Scandinavian journal of … 2016 81 उद्धरण

The role of serum vitamin D levels in vitiligo. Other

Postepy dermatologii i … 2016 59 उद्धरण

Serum Vitamin D in patients with alopecia areata. Other

Indian dermatology online … 2016 51 उद्धरण

Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. Review

Current gastroenterology reports 2016 22 उद्धरण

Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Meta-Analysis

Nutrients 2015 210 उद्धरण

Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Review

Frontiers in immunology 2015 102 उद्धरण

Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. Other

Journal of drugs … 2015 50 उद्धरण

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? Review

The Proceedings of … 2015 46 उद्धरण

Vitamin D and immune function in chronic kidney disease. Review

Clinica chimica acta; … 2015 43 उद्धरण

The Role of Vitamin D in Inflammatory Bowel Disease. Review

Healthcare (Basel, Switzerland) 2015 7 उद्धरण

Vitamin D and immunity. Review

F1000prime reports 2014 79 उद्धरण

Pediatric vitiligo. Review

Pediatric clinics of … 2014 25 उद्धरण

Vitamin D in systemic and organ-specific autoimmune diseases. Review

Clinical reviews in … 2013 259 उद्धरण

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 उद्धरण

Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. Other

Dermato-endocrinology 2013 62 उद्धरण

Vitamin D in autoimmune liver disease. Review

Clinics and research … 2013 56 उद्धरण

Multiple sclerosis. Review

Global advances in … 2013 19 उद्धरण

[Vitamin D and autoimmunity]. Review

Presse medicale (Paris, … 2013 4 उद्धरण

Vitamin D and the immune system. Review

Journal of investigative … 2011 563 उद्धरण

Vitamin D and inflammatory bowel disease. Review

Vitamins and hormones 2011 25 उद्धरण

Melanoma and vitamin D. Review

Molecular oncology 2011

The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Review

Nature clinical practice. … 2009 154 उद्धरण

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 उद्धरण

Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature. Review

Journal of the … 2006 45 उद्धरण

Chronic plaque psoriasis. Review

American family physician 2006

Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Review

Proceedings of the … 2000 281 उद्धरण

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

सामान्य रूप से उपयोग की जाने वाली खुराकें

general:: 600-800 IU/day
immunesupport:: 1,000-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)

अधिकतम सीमा: 4,000 IU/day (100 mcg)

अनुसंधान में अध्ययन की गई खुराकें

खुराक	अवधि	प्रभाव	N
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
4000 IU or 8000 IU daily	26 weeks	Positive	--
None	--	Positive	--
None	--	Neutral	--
None	--	Neutral	--

सेवन का सर्वोत्तम समय: With a meal containing fat for better absorption

Safety & Side Effects

रिपोर्ट किए गए दुष्प्रभाव

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones with excessive long-term use
⚠ Constipation
⚠ Metallic taste

ज्ञात अंतःक्रियाएँ

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

सहनीय अधिकतम सेवन: 4,000 IU/day (100 mcg)

कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।

Frequently Asked Questions

Does Vitamin D help with Autoimmune Conditions?

Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Autoimmune Conditions?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Autoimmune Conditions?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.

Related Evidence

इसके लिए अन्य सामग्री Autoimmune Conditions

Omega-3 Fatty Acids (EPA/DHA) B

Vitamin D अन्य स्वास्थ्य स्थितियों के लिए

Upper Respiratory Tract Infections A Immune Aging (Immunosenescence) B

संक्षिप्त निष्कर्ष

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest …

Evidence Strength92%

High confidence

अध्ययन विश्लेषण

RCT (4)Meta (2)Other (0)

विकल्पों की तुलना करें

देखें कि इस स्वास्थ्य स्थिति के लिए अन्य सामग्री की तुलना कैसे है।

इसके लिए सभी सामग्री देखें Autoimmune Conditions

अधिक जानें

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।