Curcumin ： Chronic Inflammation
AAn umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dcurcumin\u0026condition\u003Dchronic\u002Dinflammation';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
結論
An umbrella meta-analysis of 10 studies with 5,870 participants demonstrates curcumin supplementation may significantly reduce CRP, IL-6, and TNF-alpha inflammatory markers. Piperine co-administration increases bioavailability by approximately 2,000%.
Key Study Findings
Review
Therapeutic potential of curcumin against pancreatitis.
Dose: None
vs: None
Outcome: curcumin effects on pancreatitis via anti-inflammatory and antioxidant …
効果: None
None
対象集団: None
Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of dietary polyphenols in type 2 diabetes mellitus management
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Review
Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of NF-kB and M1 macrophages in asthma, COPD, and pulmonary fibrosis
Review
Modulating Ferroptosis in Aging: The Therapeutic Potential of Natural Products.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
10
研究数
5870
参加者数
↑
Positive
A
グレード
Referenced Papers
Arab journal of …
2026
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 件の引用
International journal of …
2025
32 件の引用
Pathology, research and …
2025
26 件の引用
Immunity & ageing …
2025
25 件の引用
Journal of aging …
2025
10 件の引用
Nutrients
2025
10 件の引用
Nutrients
2025
10 件の引用
Biomedicines
2025
8 件の引用
Materials today. Bio
2025
8 件の引用
Antioxidants (Basel, Switzerland)
2025
8 件の引用
Biology
2025
7 件の引用
Inflammopharmacology
2025
6 件の引用
International journal of …
2025
5 件の引用
Current issues in …
2025
5 件の引用
Cells
2025
4 件の引用
PNAS nexus
2025
2 件の引用
International journal of …
2025
2 件の引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 件の引用
Journal of clinical …
2024
29 件の引用
Scientific reports
2024
18 件の引用
Iranian journal of …
2024
4 件の引用
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Systematic Review
The Cochrane database …
2024
1 件の引用
Biomedicine & pharmacotherapy …
2023
115 件の引用
Current molecular pharmacology
2023
72 件の引用
International journal of …
2023
45 件の引用
Seminars in cancer …
2022
269 件の引用
Nutrition research (New …
2022
75 件の引用
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.
Review
Molecules (Basel, Switzerland)
2022
39 件の引用
Alternative therapies in …
2022
13 件の引用
Voprosy pitaniia
2022
1 件の引用
Biomedicines
2021
228 件の引用
The Journal of …
2021
117 件の引用
The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.
Review
Nutrients
2021
117 件の引用
Nutrients
2021
36 件の引用
Osteoarthritis and cartilage
2021
21 件の引用
Frontiers in medicine
2021
13 件の引用
Frontiers in physiology
2021
12 件の引用
Advances in experimental …
2021
6 件の引用
European journal of …
2020
91 件の引用
Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases.
Review
Pharmacological research
2020
65 件の引用
Brain research bulletin
2020
58 件の引用
GeroScience
2020
31 件の引用
Molecular carcinogenesis
2020
4 件の引用
Journal of cellular …
2019
212 件の引用
International journal of …
2019
137 件の引用
Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases.
Review
European cardiology
2019
80 件の引用
Frontiers in endocrinology
2019
25 件の引用
Frontiers in immunology
2018
200 件の引用
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 件の引用
Tissue barriers
2018
87 件の引用
Therapeutic Potential and Recent Advances of Curcumin in the Treatment of Aging-Associated Diseases.
Review
Molecules (Basel, Switzerland)
2018
87 件の引用
GeroScience
2018
80 件の引用
Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis.
Meta-Analysis
The American journal …
2018
30 件の引用
Advances in nutrition …
2018
28 件の引用
Current medicinal chemistry
2018
13 件の引用
Drug discovery today
2017
284 件の引用
Current pharmaceutical design
2017
168 件の引用
Science China. Life …
2017
49 件の引用
Journal of Alzheimer's …
2016
52 件の引用
Molecules (Basel, Switzerland)
2015
539 件の引用
CNS & neurological …
2014
68 件の引用
Journal of nutrigenetics …
2014
15 件の引用
BioFactors (Oxford, England)
2013
288 件の引用
Curcumin and obesity.
Review
BioFactors (Oxford, England)
2013
167 件の引用
Current pharmaceutical design
2012
54 件の引用
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 件の引用
Gut
2008
196 件の引用
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 件の引用
Current drug targets
2006
92 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,000 mg/day curcuminoids
- enhancedabsorption:
- 150-500 mg/day (phytosome or piperine formulation)
上限量： No established UL; generally well-tolerated up to 8 g/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals containing fat and black pepper (piperine) for enhanced absorption
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
- ⚠ Headache
- ⚠ Yellow stool discoloration
- ⚠ Iron absorption interference at very high doses
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Diabetes medications (may enhance blood sugar lowering)
- ● CYP1A2, CYP3A4, CYP2D6 substrates (may inhibit metabolism)
- ● Sulfasalazine and cyclophosphamide (may modify effects)
耐容上限摂取量： No established UL; generally well-tolerated up to 8 g/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Chronic Inflammation?
Based on 10 studies with 5,870 participants, there is strong evidence from multiple clinical trials that Curcumin may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).
How much Curcumin should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day curcuminoids. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Headache, Yellow stool discoloration, Iron absorption interference at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Chronic Inflammation?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 10 peer-reviewed studies with 5,870 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Chronic Inflammation
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。