Vitamin D ： Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
結論
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
効果: None
None
対象集団: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
効果: None
None
対象集団: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
効果: None
None
対象集団: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
効果: None
None
対象集団: None
Key Statistics
3
研究数
25871
参加者数
↑
Positive
A
グレード
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 件の引用
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 件の引用
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 件の引用
Immunity & ageing …
2024
12 件の引用
Frontiers in immunology
2024
9 件の引用
Autoimmunity reviews
2024
6 件の引用
Biochemical pharmacology
2024
6 件の引用
Indian dermatology online …
2024
3 件の引用
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 件の引用
Biomolecules
2023
70 件の引用
Autoimmunity reviews
2023
65 件の引用
The American journal …
2023
37 件の引用
Frontiers in immunology
2023
33 件の引用
Nutrients
2023
24 件の引用
Seminars in arthritis …
2023
17 件の引用
Mini reviews in …
2023
9 件の引用
Journal of cosmetic …
2023
4 件の引用
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 件の引用
International journal of …
2022
102 件の引用
Endocrine connections
2022
50 件の引用
Nutrients
2022
29 件の引用
Pathophysiology : the …
2022
24 件の引用
Frontiers in bioscience …
2022
17 件の引用
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 件の引用
BMJ (Clinical research …
2022
9 件の引用
Nederlands tijdschrift voor …
2022
1 件の引用
Medical sciences (Basel, …
2021
157 件の引用
International journal of …
2021
6 件の引用
JAAD international
2021
5 件の引用
Nutrients
2020
229 件の引用
Calcified tissue international
2020
185 件の引用
Nutrients
2020
41 件の引用
Acta biochimica Polonica
2020
10 件の引用
Advances in experimental …
2020
8 件の引用
Journal of autoimmunity
2019
604 件の引用
International journal of …
2019
109 件の引用
The genetics of vitamin D.
Review
Bone
2019
62 件の引用
Therapeutics and clinical …
2019
4 件の引用
Journal of research …
2018
48 件の引用
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 件の引用
Thyroid : official …
2017
170 件の引用
The Israel Medical …
2017
117 件の引用
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 件の引用
Clinical reviews in …
2017
46 件の引用
Postepy dermatologii i …
2017
31 件の引用
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 件の引用
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 件の引用
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 件の引用
Postepy dermatologii i …
2016
59 件の引用
Indian dermatology online …
2016
51 件の引用
Current gastroenterology reports
2016
22 件の引用
Nutrients
2015
210 件の引用
Frontiers in immunology
2015
102 件の引用
Journal of drugs …
2015
50 件の引用
The Proceedings of …
2015
46 件の引用
Clinica chimica acta; …
2015
43 件の引用
Healthcare (Basel, Switzerland)
2015
7 件の引用
Vitamin D and immunity.
Review
F1000prime reports
2014
79 件の引用
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 件の引用
Clinical reviews in …
2013
259 件の引用
British journal of …
2013
156 件の引用
Dermato-endocrinology
2013
62 件の引用
Clinics and research …
2013
56 件の引用
Multiple sclerosis.
Review
Global advances in …
2013
19 件の引用
Presse medicale (Paris, …
2013
4 件の引用
Journal of investigative …
2011
563 件の引用
Vitamins and hormones
2011
25 件の引用
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 件の引用
Acta medica Indonesiana
2007
4 件の引用
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 件の引用
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
上限量： 4,000 IU/day (100 mcg)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
推奨摂取タイミング： With a meal containing fat for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
既知の相互作用
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
耐容上限摂取量： 4,000 IU/day (100 mcg)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Autoimmune Conditions
Vitamin D 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。