Zinc ： Upper Respiratory Tract Infections
AMeta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dzinc\u0026condition\u003Dupper\u002Drespiratory\u002Dinfections';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
結論
Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
Key Study Findings
Observational Study
n=107
Open-label
Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …
Dose: tokishakuyakusan, zinc sulfate, methylcobalamin
vs: medication alone
Outcome: olfactory function improvement via T&T olfactometry
効果: OR=4.96
p=0.009
対象集団: patients with post-viral olfactory dysfunction (non-COVID)
Review
Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Elite/professional cyclists nutrition review
Meta-Analysis
Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …
Dose: Various oral nutritional supplements
vs: Standard diet or placebo
Outcome: Health outcomes and nutritional biomarkers
効果: None
None
対象集団: Children/adolescents with undernutrition
Controlled Clinical Trial
n=120
5 weeks
Single-blind
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …
Dose: 20 or 30 days treatment
vs: Standard treatment only (nasal aerosol)
Outcome: Otoscopy, impedance, fibroscopy, pure auditory test
効果: None
None
対象集団: Children with otitis media
Review
Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …
Dose: 31 μg
vs: None
Outcome: None
効果: None
None
対象集団: respiratory disease
Key Statistics
15
研究数
1500
参加者数
↑
Positive
A
グレード
Referenced Papers
Auris, nasus, larynx
2026
International journal of …
2025
2 件の引用
Nutrition research reviews
2025
Nutrients
2024
2 件の引用
Healthcare (Basel, Switzerland)
2022
7 件の引用
Gene reports
2021
33 件の引用
International journal of …
2021
26 件の引用
Archivio italiano di …
2019
117 件の引用
Indian journal of …
2019
3 件の引用
PloS one
2018
48 件の引用
Antimicrobial resistance and …
2018
46 件の引用
Journal of evidence-based …
2017
134 件の引用
European journal of …
2017
18 件の引用
Allergologia et immunopathologia
2016
31 件の引用
Epidemiology and infection
2016
13 件の引用
mBio
2015
414 件の引用
Antimicrobial resistance and …
2015
113 件の引用
Advances in nutrition …
2013
807 件の引用
Pakistan journal of …
2013
33 件の引用
The British journal …
2012
40 件の引用
Acta scientiarum polonorum. …
2012
11 件の引用
The British journal …
2012
2 件の引用
American family physician
2012
International journal of …
2011
49 件の引用
Nutrition journal
2011
12 件の引用
Journal of trace …
2011
11 件の引用
Arthritis research & …
2010
17 件の引用
Nihon Jibiinkoka Gakkai …
2009
1 件の引用
Alternative medicine review …
2007
163 件の引用
WITHDRAWN: Zinc for the common cold.
Systematic Review
The Cochrane database …
2007
24 件の引用
American journal of …
2006
51 件の引用
Journal of the …
2004
74 件の引用
Clinical evidence
2003
Clinical evidence
2003
Primary care
2002
56 件の引用
American family physician
2002
Canadian journal of …
2001
72 件の引用
Medical hypotheses
2001
8 件の引用
Zinc for the common cold.
Systematic Review
The Cochrane database …
2000
294 件の引用
European journal of …
1996
54 件の引用
Nederlands tijdschrift voor …
1991
European journal of …
1987
14 件の引用
Clinica chimica acta; …
1986
15 件の引用
Southern medical journal
1978
3 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 8-11 mg/day
- coldtreatment:
- 75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
- immunesupport:
- 15-30 mg/day
上限量： 40 mg/day (long-term)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| tokishakuyakusan, zinc sulfate, methylcobalamin | -- | Positive | 107 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Various oral nutritional supplements | -- | Positive | -- |
| 20 or 30 days treatment | 5 weeks | Positive | 120 |
| 31 μg | -- | Neutral | -- |
| 94.57% | -- | Mixed | -- |
| None | -- | Mixed | 387 |
推奨摂取タイミング： Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use (>40 mg/day)
- ⚠ Headache and diarrhea
既知の相互作用
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
- ● Iron supplements (mutual absorption interference when taken together)
耐容上限摂取量： 40 mg/day (long-term)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Zinc help with Upper Respiratory Tract Infections?
Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Upper Respiratory Tract Infections
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。