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ImmuneCited

Lactoferrin для Recurrent Infections

A

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

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A

Итог

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

Key Study Findings

Case Reports n=1
Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.
Dose: None или: None Outcome: None Эффект: None None

Популяция: Patient with specific granule deficiency

Randomized Controlled Trial n=48 26.0 weeks Double-blind
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, …
Dose: 500 mg или: Placebo Outcome: Disease remission Эффект: None None

Популяция: None

In Vitro
Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.
Dose: None или: Conventional antibiotics Outcome: Killing efficacy against extra- and intracellular S. aureus Эффект: None None

Популяция: In vitro S. aureus cultures

Observational Study
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.
Dose: None или: Healthy controls Outcome: Antibacterial peptide levels in Crohn's disease Эффект: Decreased defensin and LL-37 in Crohn's patients None

Популяция: Crohn's disease patients

In Vitro
Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.
Dose: None или: None Outcome: immune function Эффект: None None

Популяция: animal model

Other n=14 52.0 weeks
Abnormal nasal glandular secretion in recurrent sinusitis.
Dose: 25 mg или: baseline Outcome: oxidative stress markers Эффект: or 2 None

Популяция: general population

Key Statistics

8

Исследования

2000

Участники

Positive

A

Оценка

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
100-200 mg/day
immunesupport:
200-600 mg/day

Верхний предел: No established UL; well-tolerated up to 1,200 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Mixed 1
500 mg 26.0 weeks Positive 48
None -- Positive --
None -- Negative --
None -- Neutral --
25 mg 52.0 weeks Mixed 14
None -- Positive 60
None 468.0 weeks Mixed --

Лучшее время приёма: On empty stomach

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Generally very well tolerated
  • Mild gastrointestinal effects at high doses
  • Allergic reactions in those with cow's milk allergy
  • Constipation (rare, due to iron-binding)

Известные взаимодействия

  • May enhance absorption of certain antibiotics
  • May interact with iron supplements (iron-binding properties)

Допустимый верхний уровень потребления: No established UL; well-tolerated up to 1,200 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Lactoferrin help with Recurrent Infections?
Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Lactoferrin may support Recurrent Infections management. Our evidence grade is A (Strong Evidence).
How much Lactoferrin should I take for Recurrent Infections?
Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactoferrin?
Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactoferrin and Recurrent Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Recurrent Infections

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.