Conjugated Linoleic Acid for Chronic Inflammation
DAnimal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
The Bottom Line
Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.
Key Study Findings
Population: Review of curcumin derivatives in cancer treatment
Population: review of dietary polyphenols in type 2 diabetes mellitus management
Population: Aging adults with musculoskeletal decline (review)
Population: Patients with chronic epipharyngitis (retracted publication)
Population: Review of TCM compounds in autoimmune skin diseases
Population: None
Key Statistics
3
Studies
150
Participants
Mixed
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 1.5-3 g/day
Upper limit: No established UL
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1% zinc chloride solution | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 200 mg | 5 weeks | Positive | -- |
| None | -- | Positive | -- |
Best taken: With meals
Safety & Side Effects
Reported Side Effects
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Fatigue
- ⚠ May worsen insulin sensitivity in some individuals
- ⚠ Liver fat accumulation (some formulations)
Known Interactions
- ● Diabetes medications (may affect insulin sensitivity)
- ● Anticoagulants (may have additive effects)
Tolerable upper intake: No established UL
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Conjugated Linoleic Acid help with Chronic Inflammation?
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Are there side effects of Conjugated Linoleic Acid?
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
Related Evidence
Other ingredients for Chronic Inflammation
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.