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Zinc 관련 Upper Respiratory Tract Infections

A

Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.

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결론

Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.

Key Study Findings

Observational Study n=107 Open-label
Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …
Dose: tokishakuyakusan, zinc sulfate, methylcobalamin vs: medication alone Outcome: olfactory function improvement via T&T olfactometry 효과: OR=4.96 p=0.009

대상 집단: patients with post-viral olfactory dysfunction (non-COVID)

Review
Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …
Dose: None vs: None Outcome: None 효과: None None

대상 집단: None

Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None vs: None Outcome: None 효과: None None

대상 집단: Elite/professional cyclists nutrition review

Meta-Analysis
Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …
Dose: Various oral nutritional supplements vs: Standard diet or placebo Outcome: Health outcomes and nutritional biomarkers 효과: None None

대상 집단: Children/adolescents with undernutrition

Controlled Clinical Trial n=120 5 weeks Single-blind
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …
Dose: 20 or 30 days treatment vs: Standard treatment only (nasal aerosol) Outcome: Otoscopy, impedance, fibroscopy, pure auditory test 효과: None None

대상 집단: Children with otitis media

Review
Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …
Dose: 31 μg vs: None Outcome: None 효과: None None

대상 집단: respiratory disease

Key Statistics

15

연구

1500

참여자

Positive

A

등급

Referenced Papers

Pakistan journal of … 2013 33 인용
Acta scientiarum polonorum. … 2012 11 인용
American family physician 2012
International journal of … 2011 49 인용
Nihon Jibiinkoka Gakkai … 2009 1 인용
The Cochrane database … 2007 24 인용
Clinical evidence 2003
Clinical evidence 2003
American family physician 2002
Canadian journal of … 2001 72 인용
Zinc for the common cold. Systematic Review
The Cochrane database … 2000 294 인용
European journal of … 1996 54 인용
Nederlands tijdschrift voor … 1991
Clinica chimica acta; … 1986 15 인용
Southern medical journal 1978 3 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:
8-11 mg/day
coldtreatment:
75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
immunesupport:
15-30 mg/day

상한량: 40 mg/day (long-term)

연구에서 사용된 용량

용량 기간 효과 N
tokishakuyakusan, zinc sulfate, methylcobalamin -- Positive 107
None -- Mixed --
None -- Mixed --
Various oral nutritional supplements -- Positive --
20 or 30 days treatment 5 weeks Positive 120
31 μg -- Neutral --
94.57% -- Mixed --
None -- Mixed 387

권장 복용 시간: Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea

Safety & Side Effects

보고된 부작용

  • Nausea and vomiting (especially on an empty stomach)
  • Metallic taste in the mouth
  • Copper depletion with chronic high-dose use (>40 mg/day)
  • Headache and diarrhea

알려진 상호작용

  • Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
  • Tetracycline and quinolone antibiotics (mutual absorption reduction)
  • Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
  • Iron supplements (mutual absorption interference when taken together)

일일 최대 섭취 허용량: 40 mg/day (long-term)

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does Zinc help with Upper Respiratory Tract Infections?
Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.