Elderberry for Influenza
BMeta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
The Bottom Line
Meta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
Key Study Findings
Population: review of Sambucus nigra biological activities and phytochemistry
Population: MDCKII cells (IAV) and Calu-3 cells (SARS-CoV-2)
Population: In vitro IAV models (review)
Population: None
Population: General population
Population: COVID-19/cardiovascular populations
Key Statistics
5
Studies
500
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- acute:
- 600-900 mg/day for 3-5 days
- general:
- 150-300 mg standardized extract/day
Upper limit: No established UL; short-term use recommended
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Positive | -- |
| IC50 ~1:400 (EC 3.2), 250 nM (quinine) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
Best taken: At first sign of symptoms; within 48 hours of onset for best results
Safety & Side Effects
Reported Side Effects
- ⚠ Raw or unripe berries cause nausea, vomiting, and diarrhea (cyanogenic glycosides)
- ⚠ Mild gastrointestinal effects with prepared extracts
- ⚠ Allergic reactions (rare)
Known Interactions
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Diuretics (additive effect)
- ● Diabetes medications (may lower blood sugar)
Tolerable upper intake: No established UL; short-term use recommended
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Elderberry help with Influenza?
How much Elderberry should I take for Influenza?
Are there side effects of Elderberry?
How strong is the evidence for Elderberry and Influenza?
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.