Elderberry ： Influenza
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Meta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
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B
結論
Meta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
Key Study Findings
Review
Elderberry (Sambucus nigra L.): an ethnopharmacological, phytochemical and biological review for a prospective nutraceutical plant.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of Sambucus nigra biological activities and phytochemistry
In Vitro
Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza …
Dose: IC50 ~1:400 (EC 3.2), 250 nM (quinine)
vs: Monotherapy and untreated controls
Outcome: IAV and SARS-CoV-2 viral replication inhibition
効果: Synergy scores 14.7 (IAV), 27.8 (SARS-CoV-2)
None
対象集団: MDCKII cells (IAV) and Calu-3 cells (SARS-CoV-2)
Review
Plant extracts as a source of antiviral agents against influenza A virus.
Dose: None
vs: None
Outcome: Antiviral effects against influenza A virus
効果: None
None
対象集団: In vitro IAV models (review)
Other
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Elderberry (Sambucus nigra L.): Bioactive Compounds, Health Functions, and Applications.
Dose: None
vs: None
Outcome: Antioxidant, anti-inflammatory, antiviral effects
効果: None
None
対象集団: General population
Review
Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment.
Dose: None
vs: None
Outcome: Vascular function and antiviral properties
効果: None
None
対象集団: COVID-19/cardiovascular populations
Key Statistics
5
研究数
500
参加者数
↑
Positive
B
グレード
Referenced Papers
Inflammopharmacology
2026
Nutrients
2025
5 件の引用
Journal of applied …
2025
3 件の引用
Journal of agricultural …
2022
71 件の引用
Journal of ethnopharmacology
2022
26 件の引用
Phytotherapy research : …
2022
15 件の引用
Pharmaceuticals (Basel, Switzerland)
2022
14 件の引用
Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment.
Review
Journal of food …
2022
13 件の引用
International journal of …
2022
12 件の引用
Journal of agricultural …
2022
9 件の引用
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
Systematic Review
BMC complementary medicine …
2021
57 件の引用
Clinical nutrition ESPEN
2021
5 件の引用
Journal of general …
2020
14 件の引用
Complementary therapies in …
2019
109 件の引用
The Medical letter …
2019
Molecules (Basel, Switzerland)
2018
29 件の引用
Phytotherapy research : …
2017
98 件の引用
Nutrients
2016
98 件の引用
Phytotherapy research : …
2015
37 件の引用
Frontiers in pharmacology
2014
14 件の引用
Analytical and bioanalytical …
2013
51 件の引用
Bioscience, biotechnology, and …
2012
76 件の引用
Journal of peptide …
2012
25 件の引用
BMC complementary and …
2011
159 件の引用
Antiviral chemistry & …
2011
9 件の引用
A systematic review on the sambuci fructus effect and efficacy profiles.
Systematic Review
Phytotherapy research : …
2010
102 件の引用
Phytochemistry
2009
234 件の引用
Alternative medicine review …
2007
163 件の引用
The Journal of …
2004
240 件の引用
The Israel Medical …
2002
102 件の引用
European cytokine network
2001
Journal of alternative …
1995
187 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- acute:
- 600-900 mg/day for 3-5 days
- general:
- 150-300 mg standardized extract/day
上限量： No established UL; short-term use recommended
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| IC50 ~1:400 (EC 3.2), 250 nM (quinine) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： At first sign of symptoms; within 48 hours of onset for best results
Safety & Side Effects
報告されている副作用
- ⚠ Raw or unripe berries cause nausea, vomiting, and diarrhea (cyanogenic glycosides)
- ⚠ Mild gastrointestinal effects with prepared extracts
- ⚠ Allergic reactions (rare)
既知の相互作用
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Diuretics (additive effect)
- ● Diabetes medications (may lower blood sugar)
耐容上限摂取量： No established UL; short-term use recommended
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Elderberry help with Influenza?
Based on 5 studies with 500 participants, there is moderate evidence from clinical studies that Elderberry may support Influenza management. Our evidence grade is B (Good Evidence).
How much Elderberry should I take for Influenza?
Studies have used various dosages. A commonly studied range is 600-900 mg/day for 3-5 days. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Elderberry?
Reported side effects may include Raw or unripe berries cause nausea, vomiting, and diarrhea (cyanogenic glycosides), Mild gastrointestinal effects with prepared extracts, Allergic reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Elderberry and Influenza?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
References
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- [2] Christian Setz et al.. Nutrients. 2025. Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza A Virusa. doi:10.3390/nu17071205 PubMed
- [3] Hanushree Arumugam et al.. J Appl Microbiol. 2025. Plant extracts as a source of antiviral agents against influenza A virus. doi:10.1093/jambio/lxaf056 PubMed
- [4] Dan Liu et al.. J Agric Food Chem. 2022. Elderberry (Sambucus nigra L.): Bioactive Compounds, Health Functions, and Applications. doi:10.1021/acs.jafc.2c00010 PubMed
- [5] José Roberto Santin et al.. J Ethnopharmacol. 2022. Sambucus nigra: A traditional medicine effective in reducing inflammation in mice. doi:10.1016/j.jep.2021.114736 PubMed
- [6] Maren Eggers et al.. Phytother Res. 2022. Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus. doi:10.1002/ptr.7431 PubMed
- [7] Michał Ochnik et al.. Pharmaceuticals (Basel). 2022. Inhibition of Human Respiratory Influenza A Virus and Human Betacoronavirus-1 by the Blend of Double-Standardized Extracts of Aronia melanocarpa (Michx.) … doi:10.3390/ph15050619 PubMed
- [8] Joseph Festa et al.. J Food Biochem. 2022. Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment. doi:10.1111/jfbc.14091 PubMed
- [9] Lena Stich et al.. Int J Mol Sci. 2022. Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses. doi:10.3390/ijms23073949 PubMed
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