Elderberry لـ Influenza
B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.Meta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
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B
الخلاصة
Meta-analysis of randomized controlled trials found elderberry supplementation may substantially reduce upper respiratory symptom duration and severity when started within 48 hours of onset. One double-blind RCT showed flu symptom reduction by 3-4 days compared to placebo.
Key Study Findings
Review
Elderberry (Sambucus nigra L.): an ethnopharmacological, phytochemical and biological review for a prospective nutraceutical plant.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of Sambucus nigra biological activities and phytochemistry
In Vitro
Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza …
Dose: IC50 ~1:400 (EC 3.2), 250 nM (quinine)
مقابل: Monotherapy and untreated controls
Outcome: IAV and SARS-CoV-2 viral replication inhibition
التأثير: Synergy scores 14.7 (IAV), 27.8 (SARS-CoV-2)
None
المجتمع المدروس: MDCKII cells (IAV) and Calu-3 cells (SARS-CoV-2)
Review
Plant extracts as a source of antiviral agents against influenza A virus.
Dose: None
مقابل: None
Outcome: Antiviral effects against influenza A virus
التأثير: None
None
المجتمع المدروس: In vitro IAV models (review)
Other
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Review
Elderberry (Sambucus nigra L.): Bioactive Compounds, Health Functions, and Applications.
Dose: None
مقابل: None
Outcome: Antioxidant, anti-inflammatory, antiviral effects
التأثير: None
None
المجتمع المدروس: General population
Review
Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment.
Dose: None
مقابل: None
Outcome: Vascular function and antiviral properties
التأثير: None
None
المجتمع المدروس: COVID-19/cardiovascular populations
Key Statistics
5
الدراسات
500
المشاركون
↑
Positive
B
التقييم
Referenced Papers
Inflammopharmacology
2026
Nutrients
2025
5 اقتباسات
Journal of applied …
2025
3 اقتباسات
Journal of agricultural …
2022
71 اقتباسات
Journal of ethnopharmacology
2022
26 اقتباسات
Phytotherapy research : …
2022
15 اقتباسات
Pharmaceuticals (Basel, Switzerland)
2022
14 اقتباسات
Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment.
Review
Journal of food …
2022
13 اقتباسات
International journal of …
2022
12 اقتباسات
Journal of agricultural …
2022
9 اقتباسات
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
Systematic Review
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57 اقتباسات
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5 اقتباسات
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14 اقتباسات
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2019
109 اقتباسات
The Medical letter …
2019
Molecules (Basel, Switzerland)
2018
29 اقتباسات
Phytotherapy research : …
2017
98 اقتباسات
Nutrients
2016
98 اقتباسات
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2015
37 اقتباسات
Frontiers in pharmacology
2014
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Analytical and bioanalytical …
2013
51 اقتباسات
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2012
76 اقتباسات
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25 اقتباسات
BMC complementary and …
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Antiviral chemistry & …
2011
9 اقتباسات
A systematic review on the sambuci fructus effect and efficacy profiles.
Systematic Review
Phytotherapy research : …
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102 اقتباسات
Phytochemistry
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234 اقتباسات
Alternative medicine review …
2007
163 اقتباسات
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240 اقتباسات
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- acute:
- 600-900 mg/day for 3-5 days
- general:
- 150-300 mg standardized extract/day
الحد الأعلى: No established UL; short-term use recommended
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| IC50 ~1:400 (EC 3.2), 250 nM (quinine) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
أفضل وقت للتناول: At first sign of symptoms; within 48 hours of onset for best results
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Raw or unripe berries cause nausea, vomiting, and diarrhea (cyanogenic glycosides)
- ⚠ Mild gastrointestinal effects with prepared extracts
- ⚠ Allergic reactions (rare)
التفاعلات المعروفة
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Diuretics (additive effect)
- ● Diabetes medications (may lower blood sugar)
الحد الأقصى المسموح به: No established UL; short-term use recommended
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Elderberry help with Influenza?
Based on 5 studies with 500 participants, there is moderate evidence from clinical studies that Elderberry may support Influenza management. Our evidence grade is B (Good Evidence).
How much Elderberry should I take for Influenza?
Studies have used various dosages. A commonly studied range is 600-900 mg/day for 3-5 days. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Elderberry?
Reported side effects may include Raw or unripe berries cause nausea, vomiting, and diarrhea (cyanogenic glycosides), Mild gastrointestinal effects with prepared extracts, Allergic reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Elderberry and Influenza?
We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.
References
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- [2] Christian Setz et al.. Nutrients. 2025. Synergistic Antiviral Activity of European Black Elderberry Fruit Extract and Quinine Against SARS-CoV-2 and Influenza A Virusa. doi:10.3390/nu17071205 PubMed
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