N-Acetylcysteine ： Acute Bronchitis

Q: Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

Q: How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.

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結論

Key Study Findings

Review

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.

Dose: 20 mg/kg/day acute; 200 mg TID chronic vs: None Outcome: Efficacy in pediatric respiratory diseases 効果: None None

対象集団: Children with acute/chronic respiratory diseases

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp 効果: None None

対象集団: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency 効果: None None

対象集団: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs: None Outcome: Pain and inflammation in rheumatic diseases 効果: None None

対象集団: Patients with rheumatic diseases

Randomized Controlled Trial n=333 1.0 weeks Double-blind

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.

Dose: 600 mg vs: placebo and ambroxol Outcome: Sputum viscosity and expectoration difficulty 効果: None p<0.001

対象集団: Patients with respiratory disease and abnormal mucus

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs: Placebo 効果: None None

Key Statistics

研究数

1500

参加者数

↑

Positive

グレード

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 件の引用

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Review

Drugs in context 2025 1 件の引用

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 件の引用

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 件の引用

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. RCT

European review for … 2023 2 件の引用

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 件の引用

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 件の引用

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 件の引用

Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Other

Natural product communications 2011 7 件の引用

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 件の引用

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 件の引用

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 件の引用

[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. Review

Polski merkuriusz lekarski … 2002 16 件の引用

The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. RCT

Respirology (Carlton, Vic.) 1998 14 件の引用

[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. Other

Fortschritte der Medizin 1992

[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Other

Fortschritte der Medizin 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

上限量： No established UL; doses up to 1,800 mg/day widely studied

研究で検討された用量

用量	期間	効果	N
20 mg/kg/day acute; 200 mg TID chronic	--	Positive	--
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
600 mg	1.0 weeks	Mixed	333
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120

推奨摂取タイミング： Between meals on empty stomach for optimal absorption

Safety & Side Effects

報告されている副作用

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

既知の相互作用

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

耐容上限摂取量： No established UL; doses up to 1,800 mg/day widely studied

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Acute Bronchitis

Pelargonium sidoides A

N-Acetylcysteine 他の症状・状態について

Post-Viral Fatigue C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (4)Meta (1)Other (5)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Acute Bronchitis

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