Skip to main content
ImmuneCited

Astaxanthin 用于 氧化应激

C 证据 来自小型研究的证据有限,但存在一些积极信号。

Small randomized trials show astaxanthin supplementation may enhance IgM and IgG immunoglobulin production and T-cell function. Evidence is early-stage but consistent across multiple small trials, with astaxanthin's potent antioxidant capacity well-established.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'immunecited.com'; const params = 'ingredient\u003Dastaxanthin\u0026condition\u003Doxidative\u002Dstress'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    

Widget powered by . Free, no account required.

C

结论

Small randomized trials show astaxanthin supplementation may enhance IgM and IgG immunoglobulin production and T-cell function. Evidence is early-stage but consistent across multiple small trials, with astaxanthin's potent antioxidant capacity well-established.

Key Study Findings

Review
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease.
Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Randomized Controlled Trial n=90 8 weeks
Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and …
Dose: 8 mg/day astaxanthin vs: Control, placebo, AST alone, CT alone, CT+placebo Outcome: Oxidative stress and inflammatory markers in T2DM 效果: None <0.05

研究人群: 90 women with type 2 diabetes mellitus (6 groups, n=15)

Review
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
Dose: None vs: None Outcome: None 效果: None None

研究人群: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)

In Vitro
Astaxanthin Alleviates Oxidative Stress in Mouse Preantral Follicles and Enhances Follicular Development Through the AMPK …
Dose: 2.5 nM vs: Control follicle culture Outcome: Follicular development and oxidative stress 效果: Antrum formation 85.96% to 94.38% p<0.05

研究人群: Mouse preantral follicles in vitro culture

In Vitro
Astaxanthin Mitigates 5-Fluorouracil-Induced Hepatotoxicity and Oxidative Stress in Male Rats.
Dose: 16 and 32 mg/kg/bw vs: 5-FU induced liver damage in rats Outcome: Hepatotoxicity and oxidative stress markers 效果: None p<0.001

研究人群: Rats with 5-FU-induced liver damage

Other
Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid …
Dose: None vs: Quercetin group; oligoasthenozoospermia control mice Outcome: Sperm concentration and forward motility 效果: None None

研究人群: Cyclophosphamide-induced oligoasthenozoospermia mice

Key Statistics

3

研究数量

100

受试者

Positive

C

等级

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2025 28 次引用
Biochemical Society transactions 2024 13 次引用
Antioxidants (Basel, Switzerland) 2023 22 次引用
Molecules (Basel, Switzerland) 2022 74 次引用
Open heart 2022 52 次引用
Postepy higieny i … 2015 72 次引用
Current atherosclerosis reports 2009 122 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:
4-12 mg/day

上限: No established UL; well-tolerated up to 40 mg/day

研究中使用的剂量

剂量 持续时间 效果 N
None -- Mixed --
8 mg/day astaxanthin 8 weeks Positive 90
None -- Positive --
2.5 nM -- Positive --
16 and 32 mg/kg/bw -- Positive --
None -- Positive --
None -- Positive --
100 mg/kg/day 1 weeks Positive --

最佳服用时间: With meals containing fat

Safety & Side Effects

已报告的副作用

  • Mild orange skin discoloration at very high doses
  • Gastrointestinal discomfort
  • Generally very well tolerated

已知相互作用

  • Anticoagulants (theoretical interaction due to antioxidant effects)
  • Blood pressure medications (may have additive effects)
  • 5-alpha-reductase inhibitors (theoretical hormonal interaction)

可耐受最高摄入量: No established UL; well-tolerated up to 40 mg/day

在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Astaxanthin help with 氧化应激?
Based on 3 studies with 100 participants, there is limited but promising evidence that Astaxanthin may support 氧化应激 management. Our evidence grade is C (Some Evidence).
How much Astaxanthin should I take for 氧化应激?
Studies have used various dosages. A commonly studied range is 4-12 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Astaxanthin?
Reported side effects may include Mild orange skin discoloration at very high doses, Gastrointestinal discomfort, Generally very well tolerated. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Astaxanthin and 氧化应激?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

References

  1. [1] Mariia Shanaida et al.. Pharmaceuticals (Basel). 2025. Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications. doi:10.3390/ph18030403 PubMed
  2. [2] Jiaqi He et al.. Int J Mol Sci. 2025. Astaxanthin Alleviates Oxidative Stress in Mouse Preantral Follicles and Enhances Follicular Development Through the AMPK Signaling Pathway. doi:10.3390/ijms26052241 PubMed
  3. [3] Yasin Öztürk et al.. Nutrients. 2025. Astaxanthin Mitigates 5-Fluorouracil-Induced Hepatotoxicity and Oxidative Stress in Male Rats. doi:10.3390/nu17071230 PubMed
  4. [4] Yisa Cai et al.. J Agric Food Chem. 2025. Mechanism Exploration of Dietary Supplement Astaxanthin on Improving Atherosclerosis through an Integrated Strategy Encompassing Artificial Intelligence Virtual Screening and Experimental … doi:10.1021/acs.jafc.4c11894 PubMed
  5. [5] Ayaho Yamamoto et al.. Redox Biol. 2025. Astaxanthin protects against environmentally persistent free radical-induced oxidative stress in well-differentiated respiratory epithelium. doi:10.1016/j.redox.2025.103542 PubMed
  6. [6] Ziyu Liu et al.. Animal Model Exp Med. 2025. Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways. doi:10.1002/ame2.70000 PubMed
  7. [7] Jiarong Cui et al.. ACS Nano. 2025. Engineered Microalgal Extracellular Vesicles for Enhancing Mitochondrial Homeostasis in Radiodermatitis Prevention. doi:10.1021/acsnano.5c07135 PubMed
  8. [8] Victória Dogani Rodrigues et al.. Naunyn Schmiedebergs Arch Pharmacol. 2025. Exploring the benefits of astaxanthin as a functional food ingredient: Its effects on oxidative stress and reproductive outcomes in women … doi:10.1007/s00210-024-03432-w PubMed
  9. [9] Beata Giercuszkiewicz-Hecold et al.. Sci Rep. 2025. Astaxanthin supplementation in Arabian racing horses mitigates oxidative stress and inflammation in peripheral blood mononuclear cells through enhanced mitophagy. doi:10.1038/s41598-025-93661-7 PubMed
  10. [10] Ki-Yeon Yoo et al.. Biology (Basel). 2025. Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury. doi:10.3390/biology14091153 PubMed
  11. [11] Huang Liu et al.. Drug Des Devel Ther. 2025. Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid Metabolism and Ferroptosis. doi:10.2147/DDDT.S522738 PubMed
  12. [12] Keanie Ward et al.. Molecules. 2025. Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease. doi:10.3390/molecules30224456 PubMed
  13. [13] Aref Basereh et al.. Sci Rep. 2025. Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes. doi:10.1038/s41598-025-23914-y PubMed
  14. [14] Qiong Zhang et al.. Ecotoxicol Environ Saf. 2024. Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity. doi:10.1016/j.ecoenv.2024.115960 PubMed
  15. [15] Masoome Jabarpour et al.. Phytother Res. 2024. Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple-blind … doi:10.1002/ptr.8037 PubMed
  16. [16] Yifan Li et al.. Adv Healthc Mater. 2024. Tetrahedral Framework Nucleic Acid-Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis. doi:10.1002/adhm.202401452 PubMed
  17. [17] Manoneeta Sarker et al.. Biomed Pharmacother. 2024. Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway. doi:10.1016/j.biopha.2024.117703 PubMed
  18. [18] Opeyemi Stella Ademowo et al.. Biochem Soc Trans. 2024. Effects of carotenoids on mitochondrial dysfunction. doi:10.1042/BST20230193 PubMed
  19. [19] Callum James Joshua Queen et al.. Nutrients. 2024. The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review. doi:10.3390/nu16060826 PubMed
  20. [20] Drew E Gonzalez et al.. J Int Soc Sports Nutr. 2024. Impact of astaxanthin supplementation on markers of cardiometabolic health and tactical performance among firefighters. doi:10.1080/15502783.2024.2427751 PubMed
  21. [21] Athanasios Poulios et al.. Nutrients. 2024. The Effects of Antioxidant Supplementation on Soccer Performance and Recovery: A Critical Review of the Available Evidence. doi:10.3390/nu16223803 PubMed
  22. [22] Anahid Shafie et al.. J Ovarian Res. 2024. Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical … doi:10.1186/s13048-024-01537-7 PubMed
  23. [23] Arezoo Maleki-Hajiagha et al.. J Ovarian Res. 2024. Effect of astaxanthin supplementation on female fertility and reproductive outcomes: a systematic review and meta-analysis of clinical and animal studies. doi:10.1186/s13048-024-01472-7 PubMed
  24. [24] Jun-Hui Choi et al.. Nutrients. 2024. Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. doi:10.3390/nu16213614 PubMed
  25. [25] Jia-Xin Yu et al.. Cell Biochem Funct. 2024. Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function. doi:10.1002/cbf.70027 PubMed
  26. [26] Yunrui Cao et al.. Crit Rev Food Sci Nutr. 2023. Dietary astaxanthin: an excellent carotenoid with multiple health benefits. doi:10.1080/10408398.2021.1983766 PubMed
  27. [27] Sahar Rostami et al.. Front Endocrinol (Lausanne). 2023. Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial. doi:10.3389/fendo.2023.1144323 PubMed
  28. [28] Guihe Yang et al.. Int Immunopharmacol. 2023. Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway. doi:10.1016/j.intimp.2023.110159 PubMed
  29. [29] Mingming Deng et al.. Biomed Pharmacother. 2023. Astaxanthin attenuates cigarette smoking-induced oxidative stress and inflammation in a sirtuin 1-dependent manner. doi:10.1016/j.biopha.2023.114230 PubMed
  30. [30] Yue Tian et al.. Toxins (Basel). 2023. Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway. doi:10.3390/toxins15030232 PubMed
  31. [31] Jian Fang et al.. Acta Histochem. 2023. Astaxanthin inhibits oxidative stress and apoptosis in diabetic retinopathy. doi:10.1016/j.acthis.2023.152069 PubMed
  32. [32] Nor Hafiza Sayuti et al.. Antioxidants (Basel). 2023. Preventative and Therapeutic Effects of Astaxanthin on NAFLD. doi:10.3390/antiox12081552 PubMed
  33. [33] Deqian Kong et al.. Chem Biol Interact. 2023. Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis. doi:10.1016/j.cbi.2023.110684 PubMed
  34. [34] Sedat Kaçar et al.. J Biochem Mol Toxicol. 2023. SPC212 human mesothelioma cells underwent apoptosis, oxidative stress, and morphological deformation following Astaxanthin treatment. doi:10.1002/jbt.23415 PubMed
  35. [35] Xiaopeng Cai et al.. ACS Appl Mater Interfaces. 2022. Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury. doi:10.1021/acsami.2c10506 PubMed
  36. [36] Geir Bjørklund et al.. Molecules. 2022. The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions. doi:10.3390/molecules27217167 PubMed
  37. [37] James J DiNicolantonio et al.. Open Heart. 2022. Nutraceutical activation of Sirt1: a review. doi:10.1136/openhrt-2022-002171 PubMed
  38. [38] Lidianys María Lewis Luján et al.. Nutrients. 2022. Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration. doi:10.3390/nu14091985 PubMed
  39. [39] Baolan Ma et al.. Nutr Res. 2022. Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials. doi:10.1016/j.nutres.2021.09.005 PubMed
  40. [40] Fatemeh Abbaszadeh et al.. Neurochem Res. 2022. Astaxanthin Modulates Autophagy, Apoptosis, and Neuronal Oxidative Stress in a Rat Model of Compression Spinal Cord Injury. doi:10.1007/s11064-022-03593-1 PubMed
  41. [41] Qinghe Geng et al.. Food Funct. 2022. Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP. doi:10.1039/d2fo01673g PubMed
  42. [42] Xin Wang et al.. Mar Drugs. 2022. Simultaneous Inhibitory Effects of All-Trans Astaxanthin on Acetylcholinesterase and Oxidative Stress. doi:10.3390/md20040247 PubMed
  43. [43] Jaeeun Lee et al.. Nutrients. 2022. Astaxanthin Inhibits Oxidative Stress-Induced Ku Protein Degradation and Apoptosis in Gastric Epithelial Cells. doi:10.3390/nu14193939 PubMed
  44. [44] Antia G Pereira et al.. Mar Drugs. 2021. Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids. doi:10.3390/md19040188 PubMed
  45. [45] Xiang-Sheng Zhang et al.. Br J Pharmacol. 2021. Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice. doi:10.1111/bph.15346 PubMed
  46. [46] Jamiu Olaseni Aribisala et al.. Oxid Med Cell Longev. 2021. Astaxanthin-Mediated Bacterial Lethality: Evidence from Oxidative Stress Contribution and Molecular Dynamics Simulation. doi:10.1155/2021/7159652 PubMed
  47. [47] S J Sudharshan et al.. Biogerontology. 2021. Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae. doi:10.1007/s10522-020-09904-9 PubMed
  48. [48] Shaun A Mason et al.. Redox Biol. 2020. Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights. doi:10.1016/j.redox.2020.101471 PubMed
  49. [49] Yasin Genç et al.. Mar Drugs. 2020. Oxidative Stress and Marine Carotenoids: Application by Using Nanoformulations. doi:10.3390/md18080423 PubMed
  50. [50] Jing Zhang et al.. Bioresour Technol. 2020. Astaxanthin overproduction and proteomic analysis of Phaffia rhodozyma under the oxidative stress induced by TiO2. doi:10.1016/j.biortech.2020.123525 PubMed
  51. [51] Akshay Kumar et al.. Pharmacol Rep. 2020. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. doi:10.1007/s43440-019-00022-z PubMed
  52. [52] Hyunju Kang et al.. J Nutr Biochem. 2020. Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner. doi:10.1016/j.jnutbio.2020.108477 PubMed
  53. [53] Antonia Concetta Elia et al.. J Toxicol Environ Health A. 2019. Effects of astaxanthin and canthaxanthin on oxidative stress biomarkers in rainbow trout. doi:10.1080/15287394.2019.1648346 PubMed
  54. [54] Suhn Hyung Kim et al.. Nutrients. 2018. Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review. doi:10.3390/nu10091137 PubMed
  55. [55] Mohammad Nazmul Alam et al.. J Diet Suppl. 2018. Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats. doi:10.1080/19390211.2017.1321078 PubMed
  56. [56] Daniel R Brown et al.. Front Nutr. 2017. Astaxanthin in Exercise Metabolism, Performance and Recovery: A Review. doi:10.3389/fnut.2017.00076 PubMed
  57. [57] Yoshimi Kishimoto et al.. Mar Drugs. 2016. Potential Anti-Atherosclerotic Properties of Astaxanthin. doi:10.3390/md14020035 PubMed
  58. [58] Po-Ting Yeh et al.. PLoS One. 2016. Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats. doi:10.1371/journal.pone.0146438 PubMed
  59. [59] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
  60. [60] Md Mamun Al-Amin et al.. Behav Brain Res. 2015. Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism. doi:10.1016/j.bbr.2015.02.041 PubMed
  61. [61] Joanna Igielska-Kalwat et al.. Postepy Hig Med Dosw (Online). 2015. [Carotenoids as natural antioxidants]. doi:10.5604/17322693.1148335 PubMed
  62. [62] Robert G Fassett et al.. Future Cardiol. 2009. Astaxanthin, oxidative stress, inflammation and cardiovascular disease. doi:10.2217/fca.09.19 PubMed
  63. [63] Graziano Riccioni. Curr Atheroscler Rep. 2009. Carotenoids and cardiovascular disease. doi:10.1007/s11883-009-0065-z PubMed
  64. [64] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed

FDA 免责声明: 这些声明未经美国食品药品监督管理局(FDA)评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析,不构成医疗建议。在开始任何补充剂方案之前,请务必咨询您的医疗保健提供者。