Astaxanthin ： Oxidative Stress
CSmall randomized trials show astaxanthin supplementation may enhance IgM and IgG immunoglobulin production and T-cell function. Evidence is early-stage but consistent across multiple small trials, with astaxanthin's potent antioxidant capacity well-established.
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C
結論
Small randomized trials show astaxanthin supplementation may enhance IgM and IgG immunoglobulin production and T-cell function. Evidence is early-stage but consistent across multiple small trials, with astaxanthin's potent antioxidant capacity well-established.
Key Study Findings
Review
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Randomized Controlled Trial
n=90
8 weeks
Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and …
Dose: 8 mg/day astaxanthin
vs: Control, placebo, AST alone, CT alone, CT+placebo
Outcome: Oxidative stress and inflammatory markers in T2DM
効果: None
<0.05
対象集団: 90 women with type 2 diabetes mellitus (6 groups, n=15)
Review
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)
In Vitro
Astaxanthin Alleviates Oxidative Stress in Mouse Preantral Follicles and Enhances Follicular Development Through the AMPK …
Dose: 2.5 nM
vs: Control follicle culture
Outcome: Follicular development and oxidative stress
効果: Antrum formation 85.96% to 94.38%
p<0.05
対象集団: Mouse preantral follicles in vitro culture
In Vitro
Astaxanthin Mitigates 5-Fluorouracil-Induced Hepatotoxicity and Oxidative Stress in Male Rats.
Dose: 16 and 32 mg/kg/bw
vs: 5-FU induced liver damage in rats
Outcome: Hepatotoxicity and oxidative stress markers
効果: None
p<0.001
対象集団: Rats with 5-FU-induced liver damage
Other
Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid …
Dose: None
vs: Quercetin group; oligoasthenozoospermia control mice
Outcome: Sperm concentration and forward motility
効果: None
None
対象集団: Cyclophosphamide-induced oligoasthenozoospermia mice
Key Statistics
3
研究数
100
参加者数
↑
Positive
C
グレード
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2025
28 件の引用
International journal of …
2025
7 件の引用
Astaxanthin Mitigates 5-Fluorouracil-Induced Hepatotoxicity and Oxidative Stress in Male Rats.
Other
Nutrients
2025
7 件の引用
Journal of agricultural …
2025
6 件の引用
Redox biology
2025
6 件の引用
Animal models and …
2025
6 件の引用
ACS nano
2025
6 件の引用
Naunyn-Schmiedeberg's archives of …
2025
3 件の引用
Scientific reports
2025
3 件の引用
Biology
2025
3 件の引用
Drug design, development …
2025
2 件の引用
Molecules (Basel, Switzerland)
2025
Scientific reports
2025
Ecotoxicology and environmental …
2024
38 件の引用
Phytotherapy research : …
2024
24 件の引用
Advanced healthcare materials
2024
14 件の引用
Biomedicine & pharmacotherapy …
2024
13 件の引用
Biochemical Society transactions
2024
13 件の引用
The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review.
Review
Nutrients
2024
10 件の引用
Journal of the …
2024
10 件の引用
Nutrients
2024
9 件の引用
Journal of ovarian …
2024
9 件の引用
Journal of ovarian …
2024
8 件の引用
Nutrients
2024
5 件の引用
Cell biochemistry and …
2024
3 件の引用
Critical reviews in …
2023
105 件の引用
Frontiers in endocrinology
2023
44 件の引用
International immunopharmacology
2023
40 件の引用
Biomedicine & pharmacotherapy …
2023
30 件の引用
Toxins
2023
26 件の引用
Acta histochemica
2023
24 件の引用
Antioxidants (Basel, Switzerland)
2023
22 件の引用
Chemico-biological interactions
2023
19 件の引用
Journal of biochemical …
2023
1 件の引用
ACS applied materials …
2022
151 件の引用
Molecules (Basel, Switzerland)
2022
74 件の引用
Open heart
2022
52 件の引用
Nutrients
2022
51 件の引用
Nutrition research (New …
2022
31 件の引用
Neurochemical research
2022
13 件の引用
Food & function
2022
10 件の引用
Marine drugs
2022
10 件の引用
Nutrients
2022
9 件の引用
Marine drugs
2021
153 件の引用
British journal of …
2021
139 件の引用
Oxidative medicine and …
2021
31 件の引用
Biogerontology
2021
25 件の引用
Redox biology
2020
184 件の引用
Marine drugs
2020
59 件の引用
Bioresource technology
2020
56 件の引用
Pharmacological reports : …
2020
56 件の引用
The Journal of …
2020
43 件の引用
Journal of toxicology …
2019
33 件の引用
Nutrients
2018
253 件の引用
Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats.
Other
Journal of dietary …
2018
64 件の引用
Frontiers in nutrition
2017
68 件の引用
Marine drugs
2016
192 件の引用
PloS one
2016
127 件の引用
Molecular medicine reports
2016
48 件の引用
Behavioural brain research
2015
118 件の引用
Postepy higieny i …
2015
72 件の引用
Future cardiology
2009
176 件の引用
Current atherosclerosis reports
2009
122 件の引用
The American journal …
2008
441 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 4-12 mg/day
上限量： No established UL; well-tolerated up to 40 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| 8 mg/day astaxanthin | 8 weeks | Positive | 90 |
| None | -- | Positive | -- |
| 2.5 nM | -- | Positive | -- |
| 16 and 32 mg/kg/bw | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 100 mg/kg/day | 1 weeks | Positive | -- |
推奨摂取タイミング： With meals containing fat
Safety & Side Effects
報告されている副作用
- ⚠ Mild orange skin discoloration at very high doses
- ⚠ Gastrointestinal discomfort
- ⚠ Generally very well tolerated
既知の相互作用
- ● Anticoagulants (theoretical interaction due to antioxidant effects)
- ● Blood pressure medications (may have additive effects)
- ● 5-alpha-reductase inhibitors (theoretical hormonal interaction)
耐容上限摂取量： No established UL; well-tolerated up to 40 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Astaxanthin help with Oxidative Stress?
Based on 3 studies with 100 participants, there is limited but promising evidence that Astaxanthin may support Oxidative Stress management. Our evidence grade is C (Some Evidence).
How much Astaxanthin should I take for Oxidative Stress?
Studies have used various dosages. A commonly studied range is 4-12 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Astaxanthin?
Reported side effects may include Mild orange skin discoloration at very high doses, Gastrointestinal discomfort, Generally very well tolerated. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Astaxanthin and Oxidative Stress?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
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