Zinc 用于 Upper Respiratory Tract Infections
AMeta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
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A
结论
Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.
Key Study Findings
Observational Study
n=107
Open-label
Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …
Dose: tokishakuyakusan, zinc sulfate, methylcobalamin
vs: medication alone
Outcome: olfactory function improvement via T&T olfactometry
效果: OR=4.96
p=0.009
研究人群: patients with post-viral olfactory dysfunction (non-COVID)
Review
Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Elite/professional cyclists nutrition review
Meta-Analysis
Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …
Dose: Various oral nutritional supplements
vs: Standard diet or placebo
Outcome: Health outcomes and nutritional biomarkers
效果: None
None
研究人群: Children/adolescents with undernutrition
Controlled Clinical Trial
n=120
5 weeks
Single-blind
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …
Dose: 20 or 30 days treatment
vs: Standard treatment only (nasal aerosol)
Outcome: Otoscopy, impedance, fibroscopy, pure auditory test
效果: None
None
研究人群: Children with otitis media
Review
Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …
Dose: 31 μg
vs: None
Outcome: None
效果: None
None
研究人群: respiratory disease
Key Statistics
15
研究数量
1500
受试者
↑
Positive
A
等级
Referenced Papers
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17 次引用
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1 次引用
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2007
163 次引用
WITHDRAWN: Zinc for the common cold.
Systematic Review
The Cochrane database …
2007
24 次引用
American journal of …
2006
51 次引用
Journal of the …
2004
74 次引用
Clinical evidence
2003
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2003
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56 次引用
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2002
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72 次引用
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Zinc for the common cold.
Systematic Review
The Cochrane database …
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294 次引用
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54 次引用
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3 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 8-11 mg/day
- coldtreatment:
- 75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
- immunesupport:
- 15-30 mg/day
上限： 40 mg/day (long-term)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| tokishakuyakusan, zinc sulfate, methylcobalamin | -- | Positive | 107 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Various oral nutritional supplements | -- | Positive | -- |
| 20 or 30 days treatment | 5 weeks | Positive | 120 |
| 31 μg | -- | Neutral | -- |
| 94.57% | -- | Mixed | -- |
| None | -- | Mixed | 387 |
最佳服用时间： Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea
Safety & Side Effects
已报告的副作用
- ⚠ Nausea and vomiting (especially on an empty stomach)
- ⚠ Metallic taste in the mouth
- ⚠ Copper depletion with chronic high-dose use (>40 mg/day)
- ⚠ Headache and diarrhea
已知相互作用
- ● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
- ● Tetracycline and quinolone antibiotics (mutual absorption reduction)
- ● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
- ● Iron supplements (mutual absorption interference when taken together)
可耐受最高摄入量： 40 mg/day (long-term)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Zinc help with Upper Respiratory Tract Infections?
Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Upper Respiratory Tract Infections?
Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Upper Respiratory Tract Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Upper Respiratory Tract Infections
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