Vitamin D ： Upper Respiratory Tract Infections

Lancet 2025 meta-analysis shows vitamin D supplementation may help protect against acute respiratory infections, with strongest effects in individuals with baseline 25(OH)D levels below 25 nmol/L. Optimal protective dosing appears to be 400-1,200 IU/day rather than intermittent bolus dosing.

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結論

Key Study Findings

Review

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …

Dose: None vs: None Outcome: None 効果: None None

対象集団: Elite/professional cyclists nutrition review

Systematic Review

Interventions for preventing the progression of autosomal dominant polycystic kidney disease.

Dose: Disease-modifying agents (tolvaptan, etc.) vs: Placebo or standard care Outcome: Kidney disease progression 効果: None None

対象集団: Patients with ADPKD

Review

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …

Dose: Probiotics, nutraceuticals vs: None Outcome: Immune response modulation in COVID-19 効果: None None

対象集団: COVID-19 patients with gut dysbiosis

Review

Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature.

Dose: 600-800 IU (DRI) or higher vs: None Outcome: Skeletal and extra-skeletal health benefits 効果: None None

対象集団: General population (guideline comparison)

Meta-Analysis n=5748

High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 …

Dose: 400 IU vs: Placebo Outcome: None 効果: None None

対象集団: Healthy adults

Case-Control 26.0 weeks

Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection.

Dose: 98% vs: control Outcome: None 効果: None None

対象集団: None

Key Statistics

研究数

30000

参加者数

↑

Positive

グレード

Referenced Papers

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. Other

International journal of … 2025 2 件の引用

Revisiting Vitamin D Guidelines: A Critical Appraisal of the Literature. Review

Endocrine practice : … 2024 24 件の引用

High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and … Meta-Analysis

Nutrition reviews 2024 9 件の引用

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections. Review

Journal of translational … 2024 2 件の引用

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 件の引用

Vitamin D - An Elixir for Recurrent Upper Respiratory Tract Infection. Other

Indian journal of … 2023

Tapinarof for the treatment of psoriasis. Review

Dermatologic therapy 2022 42 件の引用

Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication … Meta-Analysis

Clinical nutrition (Edinburgh, … 2022 17 件の引用

Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. RCT

Medicine and science … 2021 18 件の引用

Vitamin D and upper respiratory tract infections in young active males exposed to cold environments. Other

Annals of agricultural … 2021 3 件の引用

Prenatal vitamin D supplementation and child respiratory health: A systematic review and meta-analysis of randomized controlled trials. Review

The World Allergy … 2020 16 件の引用

Intake of 25-Hydroxyvitamin D3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, … RCT

Nutrients 2020 1 件の引用

Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children. RCT

The Pediatric infectious … 2019 15 件の引用

Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency. Other

European archives of … 2019 14 件の引用

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes. Observational

The Journal of … 2019 9 件の引用

Infection Status of Rural Schoolchildren and its Relationship with Vitamin D Concentrations. RCT

Indian journal of … 2019 3 件の引用

Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Review

International journal of … 2018 165 件の引用

Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A … RCT

International journal of … 2018 37 件の引用

Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison … RCT

The journal of … 2018 27 件の引用

Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. RCT

JAMA 2017 131 件の引用

25-Hydroxyvitamin D supplementation and health-service utilization for upper respiratory tract infection in young children. Other

Public health nutrition 2017 6 件の引用

Vitamin D and airway infections: a European perspective. Review

European journal of … 2016 93 件の引用

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. RCT

American journal of … 2016 45 件の引用

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs. Review

Journal of general … 2016 38 件の引用

The association of residential mold exposure and adenotonsillar hypertrophy in children living in damp environments. Other

International journal of … 2016 22 件の引用

Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24 … Other

Epidemiology and infection 2016 13 件の引用

[Changes in 25-hydroxyvitamin D3 level and its significance in children with Kawasaki disease]. Other

Zhongguo dang dai … 2016 5 件の引用

The impact of sleeping with reduced glycogen stores on immunity and sleep in triathletes. RCT

European journal of … 2016

Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial. RCT

BMC infectious diseases 2014 58 件の引用

Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Other

Clinical infectious diseases … 2013 129 件の引用

Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. RCT

Clinical infectious diseases … 2013 58 件の引用

Vitamin d deficiency in e.N.T. Patients. Other

Indian journal of … 2013 24 件の引用

New actions for old nutrients. Review

Acta scientiarum polonorum. … 2012 11 件の引用

Vitamin D and tonsil disease--preliminary observations. Other

International journal of … 2011 49 件の引用

Vitamin D, innate immunity and upper respiratory tract infection. Review

The Journal of … 2010 93 件の引用

Cod liver oil, young children, and upper respiratory tract infections. Review

Journal of the … 2010 11 件の引用

Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Other

Archives of internal … 2009 975 件の引用

Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Other

Clinical journal of … 2008 148 件の引用

Alarming atrioventricular block and mitral valve prolapse in the Kearns-Sayre syndrome. Case Report

International journal of … 2002 26 件の引用

Manometric study in Kearns-Sayre syndrome. Case Report

Diseases of the … 2001 7 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 600-800 IU/day
immunesupport:: 1,000-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)

上限量： 4,000 IU/day (100 mcg)

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
Probiotics, nutraceuticals	--	Positive	--
600-800 IU (DRI) or higher	--	Positive	--
400 IU	--	Negative	5748
98%	26.0 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	50554

推奨摂取タイミング： With a meal containing fat for better absorption

Safety & Side Effects

報告されている副作用

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones with excessive long-term use
⚠ Constipation
⚠ Metallic taste

既知の相互作用

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

耐容上限摂取量： 4,000 IU/day (100 mcg)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Vitamin D help with Upper Respiratory Tract Infections?

Based on 40 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Upper Respiratory Tract Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 40 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Upper Respiratory Tract Infections

Zinc A Beta-Glucan A Vitamin C B Echinacea B Andrographis B Garlic B

Vitamin D 他の症状・状態について

Autoimmune Conditions A Immune Aging (Immunosenescence) B

総合評価

Evidence Strength92%

High confidence

研究の内訳

RCT (11)Meta (2)Other (27)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Upper Respiratory Tract Infections

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。