Iron 用于 Pediatric Immune Support

Iron supplementation in deficient children may help restore lymphocyte and neutrophil function. However, excess iron may feed pathogens and worsen infections. Supplementation should be guided by documented deficiency status.

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结论

Key Study Findings

Review

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Systematic Review and Meta-Analysis n=7014

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.

Dose: None vs: Placebo 效果: Standardized mean differences reported for each element and disease combination (specific values not None

In Vitro

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.

Dose: None vs: Minoxidil Outcome: Hair regeneration in AGA mice 效果: None None

研究人群: AGA mouse model

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 效果: None None

研究人群: Children with inflammatory bowel disease (review)

Other

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis.

Dose: None vs: Uncoated EcN and UC model mice Outcome: UC inflammation and probiotic intestinal retention 效果: None None

研究人群: Obese C57 mice with DSS-induced UC

Review

Frontal Fibrosing Alopecia in Men: A Review of the Literature.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Review of frontal fibrosing alopecia in men

Key Statistics

研究数量

400

受试者

↑

Positive

等级

Referenced Papers

Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. Other

Acta biomaterialia 2025 13 次引用

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities. Review

Cureus 2025 8 次引用

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 次引用

Engineered polyphenol-keratin nanocarriers enhance probiotic delivery and ameliorate obese ulcerative colitis. Other

Colloids and surfaces. … 2025 4 次引用

Frontal Fibrosing Alopecia in Men: A Review of the Literature. Review

Journal of clinical … 2025 1 次引用

Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. Meta-Analysis

Nutrition reviews 2025

Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Other

Journal of pineal … 2024 9 次引用

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 次引用

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 次引用

Retrospective evaluation of clinical profile and comorbidities in patients with alopecia areata. Other

Northern clinics of … 2022 7 次引用

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Review

Clinical reviews in … 2021 304 次引用

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. Other

Biomedicines 2021 27 次引用

Role of circadian rhythm disorders on EMT and tumour-immune interactions in endocrine-related cancers. Review

Endocrine-related cancer 2021 26 次引用

The impact of vitamin E and/or selenium dietary supplementation on growth parameters and expression levels of the growth-related genes in … RCT

BMC veterinary research 2021 24 次引用

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. Case Report

World journal of … 2021 10 次引用

Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. Case Report

BMC nephrology 2021 2 次引用

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn … RCT

Journal of dairy … 2020 58 次引用

Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? Other

Journal of clinical … 2019 13 次引用

Clinical Pearls on Sleep Management in Atopic Dermatitis. Review

Dermatitis : contact, … 2019 7 次引用

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and … RCT

Diabetes, obesity & … 2017 69 次引用

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 次引用

The Diagnosis and Treatment of Hair and Scalp Diseases. Review

Deutsches Arzteblatt international 2016 99 次引用

Iron Deficiency, Zinc, Magnesium, Vitamin Deficiencies in Crohn's Disease: Substitute or Not? Review

Digestive diseases (Basel, … 2016 41 次引用

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia. Other

Annals of dermatology 2016 27 次引用

The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. Other

Journal of sports … 2016 13 次引用

Protective Effects of AGE and Its Components on Neuroinflammation and Neurodegeneration. Other

Neuromolecular medicine 2016

Interventions for central serous chorioretinopathy: a network meta-analysis. Meta-Analysis

The Cochrane database … 2015 147 次引用

[Drug treatment of alopecia]. Other

Der Internist 2015

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 次引用

Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Review

International journal of … 2013 104 次引用

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 次引用

Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Review

Inflammatory bowel diseases 2012 224 次引用

Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms. Review

Sleep medicine reviews 2012 139 次引用

Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Review

Food and nutrition … 2009 122 次引用

Uses of proton pump inhibitors and serum potassium levels. Other

Pharmacoepidemiology and drug … 2009 22 次引用

Management strategies for premenstrual syndrome/premenstrual dysphoric disorder. Meta-Analysis

The Annals of … 2008 82 次引用

Hyperferritinemia in autoimmunity. Review

The Israel Medical … 2008 61 次引用

Nonhematological benefits of iron. Review

American journal of … 2007 61 次引用

Premenstrual syndrome. Systematic Review

BMJ clinical evidence 2007

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 次引用

Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice. Other

Clinical and experimental … 2006 22 次引用

Metabolic and immunologic derangements in cardiac cachexia: where to from here? Review

Heart failure reviews 2006 22 次引用

Premenstrual syndrome and premenstrual dysphoric disorder in adolescence. Review

Journal of pediatric … 2006 7 次引用

The immune system: a target for functional foods? Review

The British journal … 2002 358 次引用

Unsafe and potentially safe herbal therapies. Meta-Analysis

American journal of … 1999 226 次引用

Hair regrowth. Therapeutic agents. Review

Dermatologic clinics 1998 121 次引用

Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Other

Glia 1997 232 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 8-18 mg/day
deficiency:: Per medical guidance based on ferritin levels

上限： 45 mg/day (elemental iron)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Mixed	7014
None	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
None	--	Mixed	--
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
None	--	Positive	--

最佳服用时间： On empty stomach with vitamin C for best absorption; avoid with calcium, coffee, or tea

Safety & Side Effects

已报告的副作用

⚠ Constipation (most common)
⚠ Nausea and stomach cramps
⚠ Dark or black stools
⚠ Iron overload with excessive supplementation (hemochromatosis risk)

已知相互作用

● Calcium supplements and dairy (reduce iron absorption by 50-60%)
● Proton pump inhibitors and H2 blockers (reduce absorption)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Levothyroxine (iron reduces thyroid hormone absorption)

可耐受最高摄入量： 45 mg/day (elemental iron)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Iron help with Pediatric Immune Support?

Based on 5 studies with 400 participants, there is limited but promising evidence that Iron may support Pediatric Immune Support management. Our evidence grade is C (Some Evidence).

How much Iron should I take for Pediatric Immune Support?

Studies have used various dosages. A commonly studied range is 8-18 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Iron?

Reported side effects may include Constipation (most common), Nausea and stomach cramps, Dark or black stools, Iron overload with excessive supplementation (hemochromatosis risk). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Iron and Pediatric Immune Support?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Pediatric Immune Support

Vitamin A B

快速结论

Evidence Strength52%

Moderate confidence

研究分析

RCT (3)Meta (4)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Pediatric Immune Support

了解更多

FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。