Vitamin C 用于 Upper Respiratory Tract Infections

Research suggests regular vitamin C supplementation may reduce cold duration by approximately 8% in adults and 14% in children. Supplementation at 1g+/day is associated with reduced severity of cold symptoms. Notably, vitamin C started after symptom onset does not appear to be effective.

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结论

Key Study Findings

Review

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Elite/professional cyclists nutrition review

Review

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do?

Dose: None vs: None Outcome: Micronutrient deficiency management in pediatric IBD 效果: None None

研究人群: Children with inflammatory bowel disease (review)

Other

Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis.

Dose: 12 circulating micronutrients vs: Genetic instrument comparison Outcome: URTI, LRTI, pneumonia risk 效果: None None

研究人群: Large genetic cohort (MR analysis)

Review

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other …

Dose: Probiotics, nutraceuticals vs: None Outcome: Immune response modulation in COVID-19 效果: None None

研究人群: COVID-19 patients with gut dysbiosis

Randomized Controlled Trial

Zinc and L-Ascorbic Acid Dietary Supplementation Affected Antioxidant Status, Heat Shock Protein 70, and Some …

Dose: None vs: Basal diet without supplementation Outcome: Antioxidant status, hematology, growth in broilers 效果: None None

研究人群: Broiler chickens

Randomized Controlled Trial n=171 24 weeks Double-blind

Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged …

Dose: 12.5 billion cfu/d vs: placebo Outcome: None 效果: or 6 P=0.0300

研究人群: None

Key Statistics

研究数量

10000

受试者

↑

Positive

等级

Referenced Papers

Micronutrient Deficiencies in Pediatric IBD: How Often, Why, and What to Do? Review

Nutrients 2025 4 次引用

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. Other

International journal of … 2025 2 次引用

Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections. Review

Journal of translational … 2024 2 次引用

Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis. Other

Frontiers in nutrition 2024 1 次引用

Zinc and L-Ascorbic Acid Dietary Supplementation Affected Antioxidant Status, Heat Shock Protein 70, and Some Immunoglobulins in Japanese Quail Under … RCT

Biological trace element … 2022 5 次引用

Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial. RCT

Beneficial microbes 2021 18 次引用

Retraction Note: Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. Other

European journal of … 2021

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005-2016 NHANES. Review

Nutrients 2020 75 次引用

Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. Meta-Analysis

European journal of … 2019 54 次引用

Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies. Review

Journal of evidence-based … 2017 134 次引用

Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study. Other

European journal of … 2017 18 次引用

[Clinical features analysis of Qingkailing injection for adolescent patients based on real world HIS]. Other

Zhongguo Zhong yao … 2017

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. RCT

European journal of … 2015 70 次引用

Role of vitamins in gastrointestinal diseases. Review

World journal of … 2015 62 次引用

[Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. Other

Zhongguo Zhong yao … 2014

[Analysis of actual effects of combining xiyanping injection with vitamin C injection in treatment of upper respiratory tract infection]. Other

Zhongguo Zhong yao … 2013

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 次引用

Consumption of gold kiwifruit reduces severity and duration of selected upper respiratory tract infection symptoms and increases plasma vitamin C … RCT

The British journal … 2012 40 次引用

Treatment of the common cold in children and adults. Review

American family physician 2012

Dietary intake and supplement use of vitamins C and E and upper respiratory tract infection. Other

Journal of the … 2011 8 次引用

Vitamin C supplementation and salivary immune function following exercise-heat stress. RCT

International journal of … 2008 11 次引用

Complementary and alternative medicine for upper-respiratory-tract infection in children. Review

American journal of … 2006 51 次引用

Upper respiratory tract infection. Review

Clinical evidence 2003

Upper respiratory tract infection. Review

Clinical evidence 2003

The immune system: a target for functional foods? Review

The British journal … 2002 358 次引用

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 次引用

Upper respiratory tract infection. Other

American family physician 2002

Exercise immunology: nutritional countermeasures. Review

Canadian journal of … 2001 72 次引用

Is infection risk linked to exercise workload? Review

Medicine and science … 2000 262 次引用

Chronic exercise training effects on immune function. Review

Medicine and science … 2000 248 次引用

Natural treatment of perennial allergic rhinitis. Review

Alternative medicine review … 2000

Exercise and resistance to infection. Review

Canadian journal of … 1998 41 次引用

Immune response to heavy exertion. Review

Journal of applied … 1997 434 次引用

Exercise, immunology and upper respiratory tract infections. Review

International journal of … 1997 167 次引用

Vitamin C, neutrophil function, and upper respiratory tract infection risk in distance runners: the missing link. Review

Exercise immunology review 1997 27 次引用

Effect of ascorbic acid on increased bronchial responsiveness during upper airway infection. Other

Respiration; international review … 1989 25 次引用

Vitamin C as a preventive medicine against common colds in children. CCT

Scandinavian journal of … 1977 56 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 75-90 mg/day
acuteillness:: 1,000-2,000 mg/day
immunesupport:: 200-1,000 mg/day

上限： 2,000 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Neutral	--
12 circulating micronutrients	--	Mixed	--
Probiotics, nutraceuticals	--	Positive	--
None	--	Positive	--
12.5 billion cfu/d	24 weeks	Mixed	171
45%	988 weeks	Positive	26282
None	13.0 weeks	Mixed	3135

最佳服用时间： With meals; divide doses >500 mg for better absorption

Safety & Side Effects

已报告的副作用

⚠ Gastrointestinal distress (nausea, diarrhea, cramps) at high doses
⚠ Increased risk of kidney stones in susceptible individuals
⚠ Interference with certain lab tests (glucose, occult blood)
⚠ Iron overload risk in hemochromatosis patients

已知相互作用

● Enhances non-heme iron absorption (beneficial or harmful depending on iron status)
● High doses may reduce effectiveness of certain chemotherapy agents
● May interfere with anticoagulant therapy (warfarin) at high doses
● Aluminum-containing antacids (increased aluminum absorption)

可耐受最高摄入量： 2,000 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Vitamin C help with Upper Respiratory Tract Infections?

Based on 30 studies with 10,000 participants, there is moderate evidence from clinical studies that Vitamin C may support Upper Respiratory Tract Infections management. Our evidence grade is B (Good Evidence).

How much Vitamin C should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 75-90 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin C?

Reported side effects may include Gastrointestinal distress (nausea, diarrhea, cramps) at high doses, Increased risk of kidney stones in susceptible individuals, Interference with certain lab tests (glucose, occult blood), Iron overload risk in hemochromatosis patients. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin C and Upper Respiratory Tract Infections?

We rate the evidence as Grade B (Good Evidence). This rating is based on 30 peer-reviewed studies with 10,000 total participants. The overall direction of effect is positive.