Resveratrol ： Chronic Inflammation
CPreclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
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C
結論
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of nutrition and lifestyle interventions for dyslipidemia and cardiometabolic risk
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of NF-kB and M1 macrophages in asthma, COPD, and pulmonary fibrosis
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Key Statistics
5
研究数
300
参加者数
↑
Positive
C
グレード
Referenced Papers
ESC heart failure
2025
58 件の引用
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 件の引用
Nutrients
2025
32 件の引用
International journal of …
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32 件の引用
Pathology, research and …
2025
26 件の引用
Immunity & ageing …
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25 件の引用
Molecular neurobiology
2025
23 件の引用
Nutrients
2025
10 件の引用
Journal of aging …
2025
10 件の引用
Biomedicines
2025
8 件の引用
International journal of …
2025
5 件の引用
Current issues in …
2025
5 件の引用
International immunopharmacology
2025
3 件の引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 件の引用
Phytomedicine : international …
2025
1 件の引用
International journal of …
2024
27 件の引用
Journal of hazardous …
2024
20 件の引用
Journal of ovarian …
2024
13 件の引用
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 件の引用
Biology of reproduction
2024
9 件の引用
Oncology research
2024
8 件の引用
International journal of …
2024
3 件の引用
Zhonghua wei zhong …
2024
1 件の引用
Voprosy pitaniia
2023
19 件の引用
Cancer investigation
2023
6 件の引用
Complementary therapies in …
2022
115 件の引用
Nutrition research (New …
2022
75 件の引用
Nutrients
2022
26 件の引用
The Journal of …
2021
117 件の引用
International journal of …
2021
20 件の引用
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 件の引用
European journal of …
2020
91 件の引用
American journal of …
2020
47 件の引用
Naunyn-Schmiedeberg's archives of …
2020
37 件の引用
GeroScience
2020
31 件の引用
Scientific reports
2020
22 件の引用
Nutrients
2020
16 件の引用
Iranian journal of …
2020
5 件の引用
Molecules (Basel, Switzerland)
2019
126 件の引用
International journal of …
2018
248 件の引用
Frontiers in immunology
2018
200 件の引用
Journal of ovarian …
2018
197 件の引用
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 件の引用
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 件の引用
Current medicinal chemistry
2018
13 件の引用
Pharmacological research
2017
63 件の引用
Frontiers in neurology
2017
48 件の引用
BioMed research international
2015
22 件の引用
Current pharmacology reports
2015
Nutrition research (New …
2013
73 件の引用
Current pharmaceutical design
2012
54 件の引用
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 件の引用
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 件の引用
Current drug targets
2006
92 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
上限量： No established UL; generally well-tolerated up to 1,500 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
耐容上限摂取量： No established UL; generally well-tolerated up to 1,500 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Chronic Inflammation
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。