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Arginine для Wound Healing and Immune Recovery

B

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Итог

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

Key Study Findings

In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None или: None Outcome: Diabetic wound healing Эффект: None None

Популяция: Diabetic wound animal model

Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None или: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Эффект: None None

Популяция: Murine corneal wound model and human corneal cells

Systematic Review n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None или: Standard care or placebo Outcome: Wound healing time and wound size reduction Эффект: Wound size reduction 18.6-98.2% over 2-20 weeks None

Популяция: Adults with pressure ulcers (15 studies)

In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None или: None Outcome: Diabetic wound healing Эффект: None None

Популяция: Diabetic wound model

Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None или: None Outcome: None Эффект: None None

Популяция: Diabetes patients

In Vitro
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes.
Dose: ADI-PEG20 (PEGylated arginine deiminase) или: Vehicle control Outcome: Retinal injury and neuropathy markers Эффект: None None

Популяция: Diabetic mouse/rat models

Key Statistics

8

Исследования

600

Участники

Positive

B

Оценка

Referenced Papers

Wound repair and … 2025 2 цитирований
ACS applied materials … 2024 27 цитирований
Advanced science (Weinheim, … 2024 15 цитирований
Nutrition (Burbank, Los … 2024 12 цитирований
Biomedical materials (Bristol, … 2023 15 цитирований
International journal of … 2022 77 цитирований
The Annals of … 2022 31 цитирований
The FEBS journal 2022 8 цитирований
Advances in experimental … 2021 206 цитирований
Journal of materials … 2021 36 цитирований
The Cochrane database … 2020 33 цитирований
International journal of … 2019 265 цитирований
Biological trace element … 2017 10 цитирований
Nutrition in clinical … 2016 42 цитирований
Nutrition in clinical … 2014 131 цитирований
Critical reviews in … 2012 969 цитирований
Current opinion in … 2008 240 цитирований
Plastic and reconstructive … 2006 98 цитирований
Nutrition in clinical … 2005 247 цитирований
The Journal of … 2004 181 цитирований
Mini reviews in … 2004 178 цитирований
Wound repair and … 2003 306 цитирований
The Surgical clinics … 2003 16 цитирований
Alternative medicine review … 2003
Advances in skin … 2001 10 цитирований
The American journal … 1994 91 цитирований
JPEN. Journal of … 1994 72 цитирований
The American journal … 1983 135 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
2-3 g/day
immunesupport:
6-9 g/day

Верхний предел: No established UL; typically tolerated at 20 g/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
None -- Positive --
None -- Positive 1085
None -- Positive --
None -- Positive --
ADI-PEG20 (PEGylated arginine deiminase) -- Positive --
None -- Positive --
None -- Negative --

Лучшее время приёма: Between meals

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gastrointestinal discomfort (bloating, diarrhea, cramps)
  • Gout exacerbation (increased uric acid production)
  • Blood pressure changes
  • Worsening of herpes outbreaks (arginine supports viral replication)

Известные взаимодействия

  • Antihypertensive medications (additive blood pressure lowering)
  • PDE5 inhibitors like sildenafil (additive vasodilation)
  • Anticoagulants (may affect platelet function)
  • Potassium-sparing diuretics (arginine may increase potassium levels)

Допустимый верхний уровень потребления: No established UL; typically tolerated at 20 g/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.