Arginine ： Wound Healing and Immune Recovery
BArginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
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B
結論
Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.
Key Study Findings
In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None
vs: None
Outcome: Diabetic wound healing
効果: None
None
対象集団: Diabetic wound animal model
Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None
vs: Wild-type mice and control HCECs
Outcome: Corneal epithelial wound healing
効果: None
None
対象集団: Murine corneal wound model and human corneal cells
Systematic Review
n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None
vs: Standard care or placebo
Outcome: Wound healing time and wound size reduction
効果: Wound size reduction 18.6-98.2% over 2-20 weeks
None
対象集団: Adults with pressure ulcers (15 studies)
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
効果: None
None
対象集団: Diabetic wound model
Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Diabetes patients
In Vitro
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes.
Dose: ADI-PEG20 (PEGylated arginine deiminase)
vs: Vehicle control
Outcome: Retinal injury and neuropathy markers
効果: None
None
対象集団: Diabetic mouse/rat models
Key Statistics
8
研究数
600
参加者数
↑
Positive
B
グレード
Referenced Papers
Journal of controlled …
2025
16 件の引用
Journal of colloid …
2025
8 件の引用
Investigative ophthalmology & …
2025
4 件の引用
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Systematic Review
Wound repair and …
2025
2 件の引用
ACS applied materials …
2024
27 件の引用
Advanced science (Weinheim, …
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15 件の引用
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.
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237 件の引用
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing.
Other
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Antibacterial self-healing bilayer dressing for epidermal sensors and accelerate wound repair.
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31 件の引用
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Biomedical materials (Bristol, …
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15 件の引用
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11 件の引用
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2022
77 件の引用
A Systematic Review of Oral Nutritional Supplement and Wound Healing.
Systematic Review
The Annals of …
2022
31 件の引用
Journal of cosmetic …
2022
10 件の引用
The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.
Meta-Analysis
Nursing open
2022
9 件の引用
The FEBS journal
2022
8 件の引用
Advances in experimental …
2021
206 件の引用
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Meta-Analysis
Nutrients
2021
123 件の引用
Journal of materials …
2021
36 件の引用
Nutricion hospitalaria
2021
20 件の引用
The Cochrane database …
2020
33 件の引用
International journal of …
2019
265 件の引用
Effectiveness of Arginine Supplementation on Wound Healing in Older Adults in Acute and Chronic Settings: A Systematic Review.
Systematic Review
Advances in skin …
2019
18 件の引用
Biological trace element …
2017
10 件の引用
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2016
42 件の引用
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2015
110 件の引用
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2014
131 件の引用
Critical reviews in …
2012
969 件の引用
Current opinion in …
2009
66 件の引用
Current opinion in …
2008
240 件の引用
Nutrition and wound healing.
Review
Plastic and reconstructive …
2006
98 件の引用
Nutrition in clinical …
2005
247 件の引用
Arginine and cancer.
Review
The Journal of …
2004
181 件の引用
Mini reviews in …
2004
178 件の引用
Wound repair and …
2003
306 件の引用
Nutrition and wound healing.
Review
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2003
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 2-3 g/day
- immunesupport:
- 6-9 g/day
上限量： No established UL; typically tolerated at 20 g/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 1085 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| ADI-PEG20 (PEGylated arginine deiminase) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
推奨摂取タイミング： Between meals
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (bloating, diarrhea, cramps)
- ⚠ Gout exacerbation (increased uric acid production)
- ⚠ Blood pressure changes
- ⚠ Worsening of herpes outbreaks (arginine supports viral replication)
既知の相互作用
- ● Antihypertensive medications (additive blood pressure lowering)
- ● PDE5 inhibitors like sildenafil (additive vasodilation)
- ● Anticoagulants (may affect platelet function)
- ● Potassium-sparing diuretics (arginine may increase potassium levels)
耐容上限摂取量： No established UL; typically tolerated at 20 g/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
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