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Arginine cho Wound Healing and Immune Recovery

B

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

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Kết luận

Arginine is a key immunonutrient alongside glutamine. Supplementation may enhance immune function in surgical patients and those with malnutrition by supporting nitric oxide-dependent pathogen killing by macrophages and tissue repair.

Key Study Findings

In Vitro
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis.
Dose: None so với: None Outcome: Diabetic wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic wound animal model

Other
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3.
Dose: None so với: Wild-type mice and control HCECs Outcome: Corneal epithelial wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Murine corneal wound model and human corneal cells

Systematic Review n=1085
The Role of Glutamine and Arginine in Wound Healing of Pressure Ulcers: A Systematic Review.
Dose: None so với: Standard care or placebo Outcome: Wound healing time and wound size reduction Hiệu quả: Wound size reduction 18.6-98.2% over 2-20 weeks None

Đối tượng nghiên cứu: Adults with pressure ulcers (15 studies)

In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None so với: None Outcome: Diabetic wound healing Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic wound model

Other
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5.
Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Diabetes patients

In Vitro
Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes.
Dose: ADI-PEG20 (PEGylated arginine deiminase) so với: Vehicle control Outcome: Retinal injury and neuropathy markers Hiệu quả: None None

Đối tượng nghiên cứu: Diabetic mouse/rat models

Key Statistics

8

Nghiên cứu

600

Người tham gia

Positive

B

Xếp hạng

Referenced Papers

Advanced science (Weinheim, … 2024 15 trích dẫn
Biomedical materials (Bristol, … 2023 15 trích dẫn
International journal of … 2022 77 trích dẫn
The Annals of … 2022 31 trích dẫn
Advances in experimental … 2021 206 trích dẫn
Journal of materials … 2021 36 trích dẫn
The Cochrane database … 2020 33 trích dẫn
Biological trace element … 2017 10 trích dẫn
Nutrition in clinical … 2016 42 trích dẫn
Nutrition in clinical … 2014 131 trích dẫn
Critical reviews in … 2012 969 trích dẫn
Current opinion in … 2008 240 trích dẫn
Plastic and reconstructive … 2006 98 trích dẫn
Nutrition in clinical … 2005 247 trích dẫn
The Journal of … 2004 181 trích dẫn
Mini reviews in … 2004 178 trích dẫn
Wound repair and … 2003 306 trích dẫn
The Surgical clinics … 2003 16 trích dẫn
Alternative medicine review … 2003
Advances in skin … 2001 10 trích dẫn
The American journal … 1994 91 trích dẫn
JPEN. Journal of … 1994 72 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:
2-3 g/day
immunesupport:
6-9 g/day

Giới hạn trên: No established UL; typically tolerated at 20 g/day

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
None -- Positive --
None -- Positive --
None -- Positive 1085
None -- Positive --
None -- Positive --
ADI-PEG20 (PEGylated arginine deiminase) -- Positive --
None -- Positive --
None -- Negative --

Thời điểm dùng tốt nhất: Between meals

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Gastrointestinal discomfort (bloating, diarrhea, cramps)
  • Gout exacerbation (increased uric acid production)
  • Blood pressure changes
  • Worsening of herpes outbreaks (arginine supports viral replication)

Tương tác đã biết

  • Antihypertensive medications (additive blood pressure lowering)
  • PDE5 inhibitors like sildenafil (additive vasodilation)
  • Anticoagulants (may affect platelet function)
  • Potassium-sparing diuretics (arginine may increase potassium levels)

Mức hấp thụ tối đa cho phép: No established UL; typically tolerated at 20 g/day

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Arginine help with Wound Healing and Immune Recovery?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Arginine may support Wound Healing and Immune Recovery management. Our evidence grade is B (Good Evidence).
How much Arginine should I take for Wound Healing and Immune Recovery?
Studies have used various dosages. A commonly studied range is 2-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Arginine?
Reported side effects may include Gastrointestinal discomfort (bloating, diarrhea, cramps), Gout exacerbation (increased uric acid production), Blood pressure changes, Worsening of herpes outbreaks (arginine supports viral replication). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Arginine and Wound Healing and Immune Recovery?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

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