Resveratrol 用于 Chronic Inflammation
CPreclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
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C
结论
Preclinical models demonstrate immunomodulatory and anti-inflammatory effects through SIRT1 and NF-kB modulation. Human trials show reduction in CRP and other inflammatory markers, though low oral bioavailability remains a key limitation.
Key Study Findings
Review
Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of nutrition and lifestyle interventions for dyslipidemia and cardiometabolic risk
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Pathological interplay of NF-κB and M1 macrophages in chronic inflammatory lung diseases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of NF-kB and M1 macrophages in asthma, COPD, and pulmonary fibrosis
Review
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Key Statistics
5
研究数量
300
受试者
↑
Positive
C
等级
Referenced Papers
ESC heart failure
2025
58 次引用
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
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Nutrients
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32 次引用
International journal of …
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32 次引用
Pathology, research and …
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26 次引用
Immunity & ageing …
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25 次引用
Molecular neurobiology
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23 次引用
Nutrients
2025
10 次引用
Journal of aging …
2025
10 次引用
Biomedicines
2025
8 次引用
International journal of …
2025
5 次引用
Current issues in …
2025
5 次引用
International immunopharmacology
2025
3 次引用
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 次引用
Phytomedicine : international …
2025
1 次引用
International journal of …
2024
27 次引用
Journal of hazardous …
2024
20 次引用
Journal of ovarian …
2024
13 次引用
Antitumor Effects of Resveratrol Opposing Mechanisms of Helicobacter pylori in Gastric Cancer.
Review
Nutrients
2024
12 次引用
Biology of reproduction
2024
9 次引用
Oncology research
2024
8 次引用
International journal of …
2024
3 次引用
Zhonghua wei zhong …
2024
1 次引用
Voprosy pitaniia
2023
19 次引用
Cancer investigation
2023
6 次引用
Complementary therapies in …
2022
115 次引用
Nutrition research (New …
2022
75 次引用
Nutrients
2022
26 次引用
The Journal of …
2021
117 次引用
International journal of …
2021
20 次引用
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease.
Review
Frontiers in pharmacology
2020
144 次引用
European journal of …
2020
91 次引用
American journal of …
2020
47 次引用
Naunyn-Schmiedeberg's archives of …
2020
37 次引用
GeroScience
2020
31 次引用
Scientific reports
2020
22 次引用
Nutrients
2020
16 次引用
Iranian journal of …
2020
5 次引用
Molecules (Basel, Switzerland)
2019
126 次引用
International journal of …
2018
248 次引用
Frontiers in immunology
2018
200 次引用
Journal of ovarian …
2018
197 次引用
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Review
Pharmacological research
2018
107 次引用
MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol.
Review
Medicines (Basel, Switzerland)
2018
23 次引用
Current medicinal chemistry
2018
13 次引用
Pharmacological research
2017
63 次引用
Frontiers in neurology
2017
48 次引用
BioMed research international
2015
22 次引用
Current pharmacology reports
2015
Nutrition research (New …
2013
73 次引用
Current pharmaceutical design
2012
54 次引用
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 次引用
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Review
Molecular nutrition & …
2008
56 次引用
Current drug targets
2006
92 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 150-500 mg/day
- immunesupport:
- 250-500 mg/day trans-resveratrol
上限： No established UL; generally well-tolerated up to 1,500 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Joint pain at very high doses (>2.5 g/day)
- ⚠ Kidney issues at extremely high doses (case reports)
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● CYP1A2, CYP3A4 substrates (may inhibit metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
可耐受最高摄入量： No established UL; generally well-tolerated up to 1,500 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Resveratrol help with Chronic Inflammation?
Based on 5 studies with 300 participants, there is limited but promising evidence that Resveratrol may support Chronic Inflammation management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Chronic Inflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Chronic Inflammation
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